Evidence map›Paper›PMID 34171298›Full record

ArticleMolecular cell2021

Structural insights into the functional divergence of WhiB-like proteins in Mycobacterium tuberculosis.

Tao Wan, Magdaléna Horová, Daisy Guiza Beltran, Shanren Li, Huey-Xian Wong, Li-Mei Zhang

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. WhiB-like proteins: Diversity of structure, function and mechanism.Biochimica et biophysica acta. Molecular cell research · 2024
    Review
  7. Review
  8. Altered serine metabolism promotes drug tolerance inAntimicrobial agents and chemotherapy · 2024
    Article
  9. Metalloprotein enabled redox signal transduction in microbes.Current opinion in chemical biology · 2023
    Review
  10. Article
  11. Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tao WanDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Magdaléna HorováDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Daisy Guiza BeltranDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Shanren LiDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Huey-Xian WongDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Li-Mei ZhangDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA; Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA; Nebraska Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. Electronic address: lzhang30@unl.edu.
University of Nebraska–Lincoln · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Structures and Mechanisms of Iron-Sulfur Proteins in Redox Control and Stress ResponseR35GM138157 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZHANG, LIMEI · 2020 to 2024
$2.1M
NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R35 GM138157
6 · The paper itself

Abstract

WhiB7 represents a distinct subclass of transcription factors in the WhiB-Like (Wbl) family, a unique group of iron-sulfur (4Fe-4S] cluster-containing proteins exclusive to the phylum of Actinobacteria. In Mycobacterium tuberculosis (Mtb), WhiB7 interacts with domain 4 of the primary sigma factor (σ

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialIron-Sulfur ProteinsMycobacterium tuberculosisPromoter Regions, GeneticSigma FactorTranscription FactorsBacterial ProteinsIron-Sulfur ProteinsSigma FactorTranscription Factorsantibiotic resistanceAT-hookiron-sulfur clustertranscription factorWbl familyWhiB1WhiB7X-ray crystallographyσ(A)(4)

Identifiers

PMID34171298
PMCPMC8876573
OpenAlexW3174892098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.