Evidence map›Paper›PMID 34171207›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2021

Association between radical cystectomy prophylactic antimicrobial regimen and postoperative infection.

James Paul Joseph Ross, Rodney H Breau, Humberto Vigil, Duane R Hickling, Jonathan B Angel, Ranjeeta Mallick, Ilias Cagiannos, Christopher Morash, Luke T Lavallée

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Essential Japanese Guidelines for the Prevention of Perioperative Infections in the Urological Field: 2023 Edition.International journal of urology : official journal of the Japanese Urological Association · 2025
    Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. A survey of physician perception and practices regarding pharmacological thromboprophylaxis during chemotherapy for bladder cancer.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

James Paul Joseph RossDivision of Urology, Department of Surgery, University of Ottawa, Ottawa, ON, Canada.
Rodney H BreauDivision of Urology, Department of Surgery, University of Ottawa, Ottawa, ON, Canada.
Humberto VigilDivision of Urology, Department of Surgery, University of Ottawa, Ottawa, ON, Canada.
Duane R HicklingDivision of Urology, Department of Surgery, University of Ottawa, Ottawa, ON, Canada.
Jonathan B AngelThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ranjeeta MallickThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ilias CagiannosDivision of Urology, Department of Surgery, University of Ottawa, Ottawa, ON, Canada.
Christopher MorashDivision of Urology, Department of Surgery, University of Ottawa, Ottawa, ON, Canada.
Luke T LavalléeDivision of Urology, Department of Surgery, University of Ottawa, Ottawa, ON, Canada.
University of Ottawa · CAOttawa Hospital · CAOttawa Hospital Research Institute

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInfections are common after radical cystectomy. The objective of this study was to determine the association between antimicrobial prophylactic regimen and infection after radical cystectomy.

methodsA retrospective cohort study was performed on patients who underwent radical cystectomy at one tertiary Canadian center between January 2016 and April 2020. Patients received antimicrobial prophylaxis based on surgeon preference (cefazolin/metronidazole or ampicillin/ciprofloxacin/metronidazole, or other). A univariable and multivariable logistic regression model was created to determine the association between antimicrobial regimen and postoperative infection within 30 days. The association between patient demographic factors, as well as preoperative and intraoperative variables and infection, was also determined. Infection characteristics, including type, timing, and antimicrobial susceptibilities were reported.

resultsOne hundred and sixty-five patients were included. Mean age was 69.8 years, 121 (73.3%) were male, and 72 (43.6%) received orthotopic neobladder diversion. Ninety-six patients (58%) received cefazolin/metronidazole prophylaxis, 50 (30%) received ampicillin/ciprofloxacin/metronidazole, and 19 (11.5%) received another regimen. Fifty-four patients (32.7%) developed a postoperative infection (surgical site infection or urinary tract infection). Surgical site infection occurred in 35 patients (21.2%) and urinary tract infection occurred in 34 (21.0%). There was no association between antimicrobial regimen and incidence of postoperative infection (surgical site infection or urinary tract infection, relative risk 0.99, 95% confidence interval 0.50-1.99).

conclusionsThe overall incidence of infection was 32.7% following radical cystectomy. The preoperative prophylactic antibiotic regimen used was not associated with incidence of postoperative infection.

Identifiers

PMID34171207
PMCPMC8631847
OpenAlexW3174940758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.