Evidence map›Paper›PMID 34171150›Full record

ArticleHaemophilia : the official journal of the World Federation of Hemophilia2021

Quantitative measurements of haemophilic joint tissues by point-of-care musculoskeletal ultrasound: Associations with clinical and functional joint outcome parameters.

Akram Mesleh Shayeb, Richard F W Barnes, Cris Hanacek, Peter Aguero, Bruno Steiner, Cindy Bailey, Doris Quon, Rebecca Kruse-Jarres, Annette von Drygalski

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Haemophilia : the official journal of the World Federation of Hemophilia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Long-term prophylaxis: what are our options and how to define success?Hematology. American Society of Hematology. Education Program · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Akram Mesleh ShayebDepartment of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego, California, USA.ORCID https://orcid.org/0000-0001-7846-2326
Richard F W BarnesDepartment of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego, California, USA.
Cris HanacekDepartment of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego, California, USA.
Peter AgueroDepartment of Physical Medicine and Rehabilitation, University of California San Diego, San Diego, California, USA.
Bruno SteinerWashington Center for Bleeding Disorders, Seattle, Washington, USA.
Cindy BaileyLA Orthopedic Hemophilia Treatment Center, Orthopedic Institute for Children, Los Angeles, California, USA.
Doris QuonLA Orthopedic Hemophilia Treatment Center, Orthopedic Institute for Children, Los Angeles, California, USA.
Rebecca Kruse-JarresWashington Center for Bleeding Disorders, Seattle, Washington, USA.
Annette von DrygalskiDepartment of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego, California, USA.
University of California San Diego · USOrthopaedic Institute for Children · USWashington Center · USScripps Research Institute · USUniversity of San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPainful arthropathy is a long-term complication in patients with hemophilia (PWH), affecting mobility and quality of life. A major barrier for the appraisal of joint health is the absence of point-of-care (POC) imaging modalities to promptly identify and manage arthropathic changes. Accordingly, we developed the Joint tissue Activity and Damage Exam (JADE) POC musculoskeletal ultrasound (MSKUS) protocol. JADE is validated for haemophilic joint tissue recognition with high intra/inter-rater and inter-operator reliability.

aimsEvaluate associations of JADE with clinical (Hemophilia Joint Health Score, [HJHS]) and functional (total arc [combined flexion and extension range of motion [ROM]]) parameters. METHODOLOGY: In this multi-centre prospective study, we recruited PWH A or B with at least one arthropathic joint. We evaluated joint health (both elbows, knees, and ankles) by comparing JADE measurements (soft tissue and cartilage thickness, and osteochondral alterations) with HJHS and total arc.

resultsOf 44 PWH, most had hemophilia A (35/44), were severe (36/44) and had a median age of 36 years. Increasing HJHSs and declining total arc, indicating worsening arthropathy, were associated with JADE measurements in the expected direction, including (1) increasing length of osteochondral alterations, (2) diminished cartilage thickness, and (3) greater soft tissue expansion. The ankles had the highest proportion of joints without measurable (missing) cartilage. In multivariable models MSKUS measurements explained 68% and 71% of the variation in HJHS and total arc respectively for the elbow, 55% and 29% respectively for the knee, and 50% and 73% for the ankle.

conclusionsThis study highlights the associations of direct intra-articular ultrasonography measurements using the JADE protocol with clinical and functional parameters. Our findings underscore the clinical value of POC MSKUS using the JADE protocol as a complementary instrument for the diagnosis and management of haemophilic arthropathy.

Indexed as

Hemophilia AJoint DiseasesAdultHemarthrosisHumansKnee JointPoint-of-Care SystemsProspective StudiesQuality of LifeReproducibility of ResultsUltrasonographyarthropathyhaemophiliahemarthrosisHJHSJADEjoint diseaseMSKUSultrasound

Identifiers

PMID34171150
PMCPMC9292691
OpenAlexW3176050364

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.