Evidence map›Paper›PMID 34171007›Full record

ReviewExRNA2019

microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines.

Stephen A Leon-Icaza, Mingtao Zeng, Adrian G Rosas-Taraco

Open access · diamondAbstract readReview
In one paragraph

Review in ExRNA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 108 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. A Potential Regulatory Network of Selected Human Erythrocytic miRNAs withMicroRNA (Shariqah, United Arab Emirates) · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. miRNAs as Modern Biomarkers in Asthma Therapy.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Stephen A Leon-IcazaDepartment of Immunology, Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, NL Mexico.
Mingtao ZengCenter of Emphasis in Infectious Diseases, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, 5001 El Paso Drive, El Paso, TX 79905-2827 USA.
Adrian G Rosas-TaracoDepartment of Immunology, Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, NL Mexico.
Texas Tech University · USTexas Tech University Health Sciences Center · USUniversidad Autónoma de Nuevo León · MX

Funding

Targeted-delivery of small interference RNA against anthrax (1 R21 AI118228-01A1)R21AI118228 · NIAID · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI ZENG, MINGTAO · 2015 to 2016
$478k
NIAID NIH HHS R21 AI118228
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are single-stranded RNAs of 17-24 nt. These molecules regulate gene expression at the post-transcriptional level and are differentially expressed in viral acute respiratory infections (ARIs), which are responsible for high morbidity and mortality around the world. In recent years, miRNAs have been studied in order to discover anti-viral ARI drug targets as well as biomarkers for diagnosis, severity, and prognosis. This review presents an analysis of the regulatory response to viral ARIs of miRNAs, including their participation in the innate immune response, their utility as biomarkers, and their potential for future therapies and vaccine development.

Indexed as

CoronavirushMPVInfluenza virusmiRNARhinovirusRSVViral ARI

Identifiers

PMID34171007
PMCPMC7149109
OpenAlexW2947244263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.