ArticleNature machine intelligence2020
A topology-based network tree for the prediction of protein-protein binding affinity changes following mutation.
Article in Nature machine intelligence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it, 214 citations in OpenAlex.
- Protein Science Meets Artificial Intelligence: A Systematic Review and a Biochemical Meta-Analysis of an Inter-Field.Frontiers in bioengineering and biotechnology · 2022Pooled it
- Prot-ΔΔG: Prediction of protein-protein binding affinity changes upon mutations with pre-training strategies.Journal of computer-aided molecular design · 2026Article
- eSIG-Net: an interaction language model that decodes the protein code of single mutations.Nature methods · 2026Article
- Design of permeability-optimized target-binding macrocyclesChemical science · 2026Article
- Article
- MAMMAL - Molecular Aligned Multi-Modal Architecture and Language for biomedical discovery.npj drug discovery · 2026Article
- Enhancing mutation impact prediction in protein-protein interactions through interpretable graph-based multi-level feature interactions.Bioinformatics (Oxford, England) · 2026Article
- eSIG-Net: Accurate prediction of single-mutation induced perturbations on protein interactions using a language model.bioRxiv : the preprint server for biology · 2026Article
- A paired sequence language model for protein-protein interaction modeling.Nature communications · 2026Article
- MutPPI+: a multimodal framework for predicting mutation effects on protein-protein interactions via mutation-path-based data augmentation.Briefings in bioinformatics · 2026Article
- DSSA-PPI: enhancing binding affinity change prediction upon protein mutations using disentangled structure-sequence aware attention.Chemical science · 2026Article
- Exploring antibody-antigen binding affinity using degree-based topological indices: a graph-theoretical approach.Frontiers in chemistry · 2026Article
- Predicting Protein-Protein Interactions from Machine-Learned Representations.Advances in experimental medicine and biology · 2026Review
- A Review of Topological Data Analysis and Topological Deep Learning in Molecular Sciences.Journal of chemical information and modeling · 2025Review
- Topological machine learning for protein-nucleic acid binding affinity changes upon mutation.Machine learning: science and technology · 2025Article
- PPAC: Predicting Protein-Protein Affinity Changes Induced by Amino Acid Mutations Using Protein Large Language Models.ACS omega · 2025Article
- A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodies.Cell discovery · 2025Article
- Article
- Sequence-only prediction of binding affinity changes: a robust and interpretable model for antibody engineering.Bioinformatics (Oxford, England) · 2025Article
- Investigating the volume and diversity of data needed for generalizable antibody-antigen ΔΔG prediction.Nature computational science · 2025Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The ability to predict protein-protein interactions is crucial to our understanding of a wide range of biological activities and functions in the human body, and for guiding drug discovery. Despite considerable efforts to develop suitable computational methods, predicting protein-protein interaction binding affinity changes following mutation (ΔΔ
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.