ArticlePloS one2021
Fatty infiltration in cervical flexors and extensors in patients with degenerative cervical myelopathy using a multi-muscle segmentation model.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Muscle fat infiltration and its relation with pain intensity, disability, and cervical curvature in individuals with nonspecific neck pain: A systematic review study.PM & R : the journal of injury, function, and rehabilitation · 2026Pooled it
- Sarcopenia as a predictor of poor functional outcome of cervical spine surgery: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- A Magnetic Resonance Imaging (MRI) Investigation of Cervical Spine Muscle Characteristics After Concussion: Identifying Return-to-Play Clearance and Subsequent Injury Prognosis.Journal of child neurology · 2026Article
- Cervical Multifidus Fatty Degeneration and Bony Foraminal Stenosis Are Associated with Unsuccessful Response to Stellate Ganglion Block in Cervical Radicular Pain: A Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Article
- Radiological differences between patients with degenerative cervical myelopathy according to different levels of maximum compression.BMC musculoskeletal disorders · 2026Article
- Relationship Between Paraspinal Muscle Degeneration and Functional Outcomes Following Anterior Cervical Spine Surgery for Degenerative Disk Disease: A Systematic Review.Journal of clinical medicine · 2025Review
- What is normal age-related thigh muscle composition among 45- to 84-year-old adults from the UK Biobank study.GeroScience · 2025Article
- MuscleMap: An Open-Source, Community-Supported Consortium for Whole-Body Quantitative MRI of Muscle.Journal of imaging · 2024Review
- Reduced Cervical Muscle Fat Infiltrate Is Associated with Self-Reported Recovery from Chronic Idiopathic Neck Pain Over Six Months: A Magnetic Resonance Imaging Longitudinal Cohort Study.Journal of clinical medicine · 2024Article
- Study on the consistency between CT hounsfield units and MRI evaluation of preoperative cervical paraspinal muscular fat infiltration in patients undergoing ACDF.Journal of orthopaedic surgery and research · 2024Article
- Morphological Changes of Deep Extensor Neck Muscles in Relation to the Maximum Level of Cord Compression and Canal Compromise in Patients With Degenerative Cervical Myelopathy.Global spine journal · 2024Article
- Three-dimensional freehand ultrasonography to measure muscle volume of the lumbar multifidus: Reliability of processing technique and validity through comparison to magnetic resonance imaging.Journal of anatomy · 2024Article
- Effects of Cervical Paravertebral Extensors in Patients with Cervical Ossification of the Posterior Longitudinal Ligament Grouped According to mK-Line.Orthopaedic surgery · 2024Article
- Artificial Intelligence in Spine and Paraspinal Muscle Analysis.Advances in experimental medicine and biology · 2024Review
- Exploring the latest advancements in physical therapy techniques for treating cervical spondylosis patients: A narrative review.Biomolecules & biomedicine · 2023Review
- Association between fatty infiltration in the cervical multifidus and treatment response following cervical interlaminar epidural steroid injection.The Korean journal of pain · 2023Article
- Cervical muscle morphometry and composition demonstrate prognostic value in degenerative cervical myelopathy outcomes.Frontiers in neurology · 2023Article
- The fatty infiltration into cervical paraspinal muscle as a predictor of postoperative outcomes: A controlled study based on hybrid surgery.Frontiers in endocrinology · 2023Article
- Greater muscle volume and muscle fat infiltrate in the deep cervical spine extensor muscles (multifidus with semispinalis cervicis) in individuals with chronic idiopathic neck pain compared to age and sex-matched asymptomatic controls: a cross-sectional study.BMC musculoskeletal disorders · 2022Article
- Fat Infiltration of Multifidus Muscle Is Correlated with Neck Disability in Patients with Non-Specific Chronic Neck Pain.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundIn patients with degenerative cervical myelopathy (DCM) that have spinal cord compression and sensorimotor deficits, surgical decompression is often performed. However, there is heterogeneity in clinical presentation and post-surgical functional recovery.
objectivesPrimary: a) to assess differences in muscle fat infiltration (MFI) in patients with DCM versus controls, b) to assess association between MFI and clinical disability. Secondary: to assess association between MFI pre-surgery and post-surgical functional recovery. STUDY
designCross-sectional case control study.
methodsEighteen patients with DCM (58.6 ± 14.2 years, 10 M/8F) and 25 controls (52.6 ± 11.8 years, 13M/12 F) underwent 3D Dixon fat-water imaging. A convolutional neural network (CNN) was used to segment cervical muscles (MFSS- multifidus and semispinalis cervicis, LC- longus capitis/colli) and quantify MFI. Modified Japanese Orthopedic Association (mJOA) and Nurick were collected.
resultsPatients with DCM had significantly higher MFI in MFSS (20.63 ± 5.43 vs 17.04 ± 5.24, p = 0.043) and LC (18.74 ± 6.7 vs 13.66 ± 4.91, p = 0.021) than controls. Patients with increased MFI in LC and MFSS had higher disability (LC: Nurick (Spearman's ρ = 0.436, p = 0.003) and mJOA (ρ = -0.399, p = 0.008)). Increased MFI in LC pre-surgery was associated with post-surgical improvement in Nurick (ρ = -0.664, p = 0.026) and mJOA (ρ = -0.603, p = 0.049).
conclusionIn DCM, increased muscle adiposity is significantly associated with sensorimotor deficits, clinical disability, and functional recovery after surgery. Accurate and time efficient evaluation of fat infiltration in cervical muscles may be conducted through implementation of CNN models.
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