Evidence map›Paper›PMID 34170795›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Early Lung Disease Exhibits Bacteria-Dependent and -Independent Abnormalities in Cystic Fibrosis Pigs.

Drake C Bouzek, Mahmoud H Abou Alaiwa, Ryan J Adam, Alejandro A Pezzulo, Leah R Reznikov, Daniel P Cook, Maria I Aguilar Pescozo, Patrick Ten Eyck, Chaorong Wu, Thomas J Gross and 4 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  2. Article
  3. A chronicInfection and immunity · 2025
    Article
  4. Article
  5. Development and Initial Characterization of Pigs withbioRxiv : the preprint server for biology · 2024
    Article
  6. INSIGHTS INTO THE ORIGINS OF CYSTIC FIBROSIS LUNG DISEASE.Transactions of the American Clinical and Climatological Association · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Early Antibiotics in Cystic Fibrosis: Lessons from the Cystic Fibrosis Pig Model.American journal of respiratory and critical care medicine · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Drake C BouzekDepartment of Internal Medicine.
Mahmoud H Abou AlaiwaDepartment of Internal Medicine.
Ryan J AdamDepartment of Internal Medicine.
Alejandro A PezzuloDepartment of Internal Medicine.
Leah R ReznikovDepartment of Internal Medicine.ORCID 0000-0002-4074-9070
Daniel P CookDepartment of Internal Medicine.ORCID 0000-0002-1152-4454
Maria I Aguilar PescozoDepartment of Internal Medicine.
Patrick Ten EyckInstitute for Clinical and Translational Science.
Chaorong WuInstitute for Clinical and Translational Science.
Thomas J GrossDepartment of Internal Medicine.
Douglas B HornickDepartment of Internal Medicine.
Eric A HoffmanDepartment of Biomedical Engineering.
David K MeyerholzDepartment of Pathology, and.
David A StoltzDepartment of Internal Medicine.ORCID 0000-0003-0893-9015
University of Iowa Health Care · US

Funding

Vector CoreP01HL051670 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 1993 to 2019
$36.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
Multidisciplinary Lung Research Career Development ProgramT32HL007638 · NHLBI · UNIVERSITY OF IOWA · PI WELSH, MICHAEL J., ZABNER, JOSEPH · 1986 to 2020
$16.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
Airway Alkalinization and Repurposing Tromethamine as a Therapeutic Approach in Cystic FibrosisR01HL136813 · NHLBI · UNIVERSITY OF IOWA · PI STOLTZ, DAVID A, ZABNER, JOSEPH · 2017 to 2021
$5.3M
SHORT-TERM TRAINING: STUDENTS IN HEALTH PROF. SCHOOLST35HL007485 · NHLBI · UNIVERSITY OF IOWA · PI ROGHAIR, ROBERT D · 1985 to 2019
$4.3M
Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
Ultra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0M
Mechanisms of impaired mucociliary transport in CF airway diseaseK08HL135433 · NHLBI · UNIVERSITY OF IOWA · PI ABOU ALAIWA, MAHMOUD · 2017 to 2021
$801k
Heat-shock protein 90 modulates goblet cell metaplasia in human airway epitheliaK01HL140261 · NHLBI · UNIVERSITY OF IOWA · PI PEZZULO, ALEJANDRO ANTONIO · 2019 to 2023
$746k
NCATS NIH HHS UL1 TR002537NHLBI NIH HHS K01 HL140261NHLBI NIH HHS K08 HL135433NHLBI NIH HHS P01 HL051670NHLBI NIH HHS P01 HL091842NHLBI NIH HHS R01 HL136813NHLBI NIH HHS T32 HL007638NHLBI NIH HHS T32 HL134643NHLBI NIH HHS T35 HL007485NIDDK NIH HHS P30 DK054759NIGMS NIH HHS T32 GM007337NIH HHS S10 OD018526
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAnti-Bacterial AgentsBacteriaBronchoalveolar Lavage FluidCystic FibrosisLungMultidetector Computed TomographyRespiratory MucosaSwineAnti-Bacterial Agentsantibacterial agentslung physiologymucusmultidetector computed tomographyrespiratory mucosa

Identifiers

PMID34170795
PMCPMC8521711
OpenAlexW3177478456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.