Evidence map›Paper›PMID 34170784›Full record

ArticleHuman vaccines & immunotherapeutics2021

Synergistic immune and antinociceptive effects induced from the combination of two different vaccines against morphine/heroin in mouse.

Susana Barbosa-Mendez, Maura Matus-Ortega, Ricardo Hernandez-Miramontes, Alberto Salazar-Juárez

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. NICBrain sciences · 2025
    Article
  2. Article
  3. Opioid-Based Haptens: Development of Immunotherapy.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Susana Barbosa-MendezLaboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, México, México.
Maura Matus-OrtegaLaboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, México, México.
Ricardo Hernandez-MiramontesLaboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, México, México.
Alberto Salazar-JuárezLaboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, México, México.ORCID 0000-0003-1787-1657
Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz · MX

Funding

Preclinical studies of a heroin/morphine vaccine for opiate addictionR01DA030715 · NIDA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI PENTEL, PAUL R · 2010 to 2014
$2.9M
NIDA NIH HHS R01 DA030715
6 · The paper itself

Abstract

Animal studies have reported the use of different opioid-vaccine formulations with relative success These studies have suggested that new opioid-vaccine formulations are required, which are capable of triggering a robust humoral response. One strategy that has been used is the co-administration of two or more vaccines with different but complementary properties, which are capable of generating a robust immune response. We have developed two formulations of opioid-vaccine, the M

Indexed as

HeroinVaccinesAnalgesics, OpioidAnimalsMiceMice, Inbred BALB CMorphineMorphine DerivativesAnalgesics, OpioidHeroinMorphineMorphine DerivativesVaccinesactive vaccinationantibodiesheroinmorphineOpioid-drugsVaccine

Identifiers

PMID34170784
PMCPMC8437472
OpenAlexW3174390831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.