Evidence map›Paper›PMID 34170697›Full record

ArticleThe journal of physical chemistry letters2021

Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant.

Ryan A Herold, Raphael Reinbold, Clare F Megarity, Martine I Abboud, Christopher J Schofield, Fraser A Armstrong

Abstract read
In one paragraph

Article in The journal of physical chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Electroenzymatic COAngewandte Chemie (International ed. in English) · 2026
    Review
  2. Lessons, connections, hypotheses and predictions from protein film electrochemistry.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Review
  3. Review
  4. Building Localized NADP(H) Recycling Circuits to Advance Enzyme Cascadetronics.Angewandte Chemie (International ed. in English) · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. NADP(H)-dependent biocatalysis without adding NADP(H).Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryan A HeroldDepartment of Chemistry, University of Oxford, Oxford OX1 3QR, United Kingdom.ORCID https://orcid.org/0000-0001-7935-6269
Raphael ReinboldDepartment of Chemistry, University of Oxford, Oxford OX1 3QR, United Kingdom.
Clare F MegarityDepartment of Chemistry, University of Oxford, Oxford OX1 3QR, United Kingdom.
Martine I AbboudDepartment of Chemistry, University of Oxford, Oxford OX1 3QR, United Kingdom.ORCID https://orcid.org/0000-0003-2141-5988
Christopher J SchofieldDepartment of Chemistry, University of Oxford, Oxford OX1 3QR, United Kingdom.ORCID https://orcid.org/0000-0002-0290-6565
Fraser A ArmstrongDepartment of Chemistry, University of Oxford, Oxford OX1 3QR, United Kingdom.ORCID https://orcid.org/0000-0001-8041-2491

Funding

Wellcome Trust
6 · The paper itself

Abstract

Human isocitrate dehydrogenase (IDH1) and its cancer-associated variant (IDH1 R132H) are rendered electroactive through coconfinement with a rapid NADP(H) recycling enzyme (ferredoxin-NADP

Indexed as

EnzymesMutationElectrodesHumansIsocitrate DehydrogenaseKineticsNanotechnologyNeoplasmsOxidation-ReductionThermodynamicsEnzymesIsocitrate Dehydrogenase

Identifiers

PMID34170697
PMCPMC8273889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.