ArticleACS applied materials & interfaces2021
Silk Hydrogel Substrate Stress Relaxation Primes Mesenchymal Stem Cell Behavior in 2D.
Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- The Impact of S-220-Loaded Silk Hydrogels on In Vitro Neurite Outgrowth in 2 and 3 Dimensions.Advanced biology · 2026Article
- Biophysical signal-driven scaffold design for stem cell-guided osteochondral regeneration.Bioactive materials · 2026Review
- Impact of the Chronic Ischemic Stroke Microenvironment on Silk Fibroin Hydrogel Biodegradation andACS omega · 2026Article
- Evaluation of Colombian silk fibroin hydrogels functionalized with recombinant LSECtin for intervertebral disc tissue engineering.PloS one · 2026Article
- Cell biomechanics on muscle atrophy: from intricate mechanisms to therapeutic frontiers.Annals of medicine · 2025Review
- Controlled Fabrication of pH-Visualised Silk Fibroin-Sericin Dual-Network Hydrogels for Urine Detection in Diapers.Gels (Basel, Switzerland) · 2025Article
- Matrix stiffness and viscoelasticity influence human mesenchymal stem cell immunomodulation.Mechanobiology in medicine · 2025Article
- Functionalising silk hydrogels with hetero- and homotypic nanoparticles.RSC advances · 2024Article
- RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells.Frontiers in bioengineering and biotechnology · 2024Article
- Microfibre-Functionalised Silk Hydrogels.Cells · 2023Article
- Dynamic Hydrogels with Viscoelasticity and Tunable Stiffness for the Regulation of Cell Behavior and Fate.Materials (Basel, Switzerland) · 2023Review
- Elastin-like protein hydrogels with controllable stress relaxation rate and stiffness modulate endothelial cell function.Journal of biomedical materials research. Part A · 2023Article
- Viscoelastic hydrogels for interrogating pancreatic cancer-stromal cell interactions.Materials today. Bio · 2023Article
- Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering.Polymers · 2022Review
- Impact of silk hydrogel secondary structure on hydrogel formation, silk leaching and in vitro response.Scientific reports · 2022Article
- A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair.Frontiers in bioengineering and biotechnology · 2022Review
- Mechanisms of hydrogel-based microRNA delivery systems and its application strategies in targeting inflammatory diseases.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue-mimetic silk hydrogels are being explored for diverse healthcare applications, including stem cell delivery. However, the impact of stress relaxation of silk hydrogels on human mesenchymal stem cell (MSC) biology is poorly defined. The aim of this study was to fabricate silk hydrogels with tuned mechanical properties that allowed the regulation of MSC biology in two dimensions. The silk content and stiffness of both elastic and viscoelastic silk hydrogels were kept constant to permit direct comparisons. Gene expression of
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Registered trials
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