ArticleAngewandte Chemie (International ed. in English)2021
Nanoscale Chemical Imaging of Supported Lipid Monolayers using Tip-Enhanced Raman Spectroscopy.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Nanoscale Chemical Analysis of Heterogeneous Catalysts Using Tip-Enhanced Raman Spectroscopy.Chemical reviews · 2026Review
- Molecular states and interfacial interactions at solid-liquid interfaces: advances and challenges in multimodal characterization.Beilstein journal of nanotechnology · 2026Review
- Hyperspectral TERS Imaging Reveals Strain Heterogeneity in Individual Nanoplastic Particles.Nano letters · 2025Article
- Raman analysis of lipids in cells: Current applications and future prospects.Journal of pharmaceutical analysis · 2025Review
- Chaotropic Agent-Assisted Supported Lipid Bilayer Formation.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Deterministic grayscale nanotopography to engineer mobilities in strained MoSNature communications · 2024Article
- Nanoscale visualization of phase separation in binary supported lipid monolayer using tip-enhanced Raman spectroscopy.Nanoscale · 2024Article
- Nanoscale Chemical Analysis of Thin Film Solar Cell Interfaces Using Tip-Enhanced Raman Spectroscopy.ACS applied materials & interfaces · 2024Article
- Probing Chemical Complexity of Amyloid Plaques in Alzheimer's Disease Mice using Hyperspectral Raman Imaging.ACS chemical neuroscience · 2024Article
- Nanoscale chemical analysis of 2D molecular materials using tip-enhanced Raman spectroscopy.Nanoscale · 2023Review
- Near-field optical microscopy toward its applications for biological studies.Biophysics and physicobiology · 2023Article
- Nanoscale Chemical Imaging of Human Cell Membranes Using Tip-Enhanced Raman Spectroscopy.Angewandte Chemie (International ed. in English) · 2022Article
- Nanoscale Chemical Imaging of Supported Lipid Monolayers using Tip-Enhanced Raman Spectroscopy.Angewandte Chemie (International ed. in English) · 2021Article
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4 authors.
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Abstract
Visualizing the molecular organization of lipid membranes is essential to comprehend their biological functions. However, current analytical techniques fail to provide a non-destructive and label-free characterization of lipid films under ambient conditions at nanometer length scales. In this work, we demonstrate the capability of tip-enhanced Raman spectroscopy (TERS) to probe the molecular organization of supported DPPC monolayers on Au (111), prepared using the Langmuir-Blodgett (LB) technique. High-quality TERS spectra were obtained, that permitted a direct correlation of the topography of the lipid monolayer with its TERS image for the first time. Furthermore, hyperspectral TERS imaging revealed the presence of nanometer-sized holes within a continuous DPPC monolayer structure. This shows that a homogeneously transferred LB monolayer is heterogeneous at the nanoscale. Finally, the high sensitivity and spatial resolution down to 20 nm of TERS imaging enabled reproducible, hyperspectral visualization of molecular disorder in the DPPC monolayers, demonstrating that TERS is a promising nanoanalytical tool to investigate the molecular organization of lipid membranes.
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