Evidence map›Paper›PMID 34170582›Full record

ArticleScandinavian journal of medicine & science in sports2021

The importance of ventilatory thresholds to define aerobic exercise intensity in cardiac patients and healthy subjects.

Francesca Anselmi, Luna Cavigli, Antonio Pagliaro, Serafina Valente, Francesca Valentini, Matteo Cameli, Marta Focardi, Nicola Mochi, Paul Dendale, Dominique Hansen and 3 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Scandinavian journal of medicine & science in sports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07792642 (FITME Study), which is not on this map. Cited by 49 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 4 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07792642 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

FITME Study: Formulating Individualised Exercise Prescription in Chronic Obstructive Pulmonary Disease

TypeinterventionalSponsorAveiro UniversityRan2026 to 2029Enrolled46ConditionsChronic Obstructive Pulmonary Disease (COPD)ArmsNon-pharmacological intervention: Pulmonary rehabilitation programme
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  11. Article
  12. Assessing Training Zones in Adult Men with Obesity: A New Field Test.Journal of functional morphology and kinesiology · 2026
    Article
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  19. Review
  20. Cognitive correlates of human endurance.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Francesca AnselmiDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Luna CavigliDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Antonio PagliaroClinical and Surgical Cardiology Unit, Cardio-Thoracic and Vascular Department, University Hospital of Siena, Siena, Italy.
Serafina ValenteClinical and Surgical Cardiology Unit, Cardio-Thoracic and Vascular Department, University Hospital of Siena, Siena, Italy.
Francesca ValentiniDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Matteo CameliDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0003-3872-8964
Marta FocardiDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Nicola MochiSports Medicine Unit, USL Toscana Centro, Florence, Italy.
Paul DendaleHeartcentre Hasselt, Jessa Hospital, Hasselt University, Hasselt, Belgium.
Dominique HansenREVAL-Rehabilitation Research Center, BIOMED, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium.
Marco BonifaziDepartment of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Martin HalleDepartment of Preventive Sports Medicine and Sports Cardiology, Technical University of Munich, Munich, Germany.ORCID https://orcid.org/0000-0003-3065-530X
Flavio D'AscenziDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0002-0947-6836
University of Siena · ITAzienda Usl Toscana Centro · ITHasselt University · BEJessa Hospital · BETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough structured exercise training is strongly recommended in cardiac patients, uncertainties exist about the methods for determining exercise intensity (EI) and their correspondence with effective EI obtained by ventilatory thresholds. We aimed to determine the first (VT

methodsWe prospectively enrolled 350 subjects (mean age: 50.7±12.9 years; 167 cardiac patients, 150 healthy sedentary subjects, and 33 competitive endurance athletes). Each subject underwent ECG, echocardiography, and cardiopulmonary exercise testing. The percentages of peak VO

resultsVO

conclusionsEI definition based on percentages of peak HR and peak VO

Indexed as

AthletesSedentary BehaviorAdultEchocardiographyExerciseExercise TestFemaleHeart DiseasesHeart RateHumansMaleMiddle AgedOxygen ConsumptionPhysical EnduranceProspective StudiesPulmonary Ventilationcardiopulmonary exercise testingexercise intensityexercise prescriptionlactateventilatory threshold

Identifiers

PMID34170582
PMCPMC8456830
OpenAlexW3176138349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.