ArticleJournal of nephrology2022
Outcomes and rates of dissolution therapy for uric acid stones.
Article in Journal of nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Staghorn uric acid stones: oral chemolysis outcomes and development of a nomogram for treatment success.Urolithiasis · 2026Article
- Flexible ureteroscopy combined with potassium sodium hydrogen citrate(PSHC) intervention improves the stone-free rate(SFR) for 20-30 mm uric acid renal stones.BMC urology · 2025Article
- Medical treatment of uric acid kidney stones.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Article
- Development and external validation of a machine learning-based model to classify uric acid stones in patients with kidney stones of Hounsfield units < 800.Urolithiasis · 2023Article
- Effect of theobromine on dissolution of uric acid kidney stones.World journal of urology · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo describe the outcomes and quantify the rate of uric acid stone medical dissolution therapy using automated, software-generated stone volume measurements.
methodsA sample of patients treated with oral dissolution therapy was reviewed from a single institution between 2008 and 2019. Baseline patient demographics, metabolic urine testing and stone characteristics were collected. Computed tomography (CT) scan images were evaluated using the quantitative Stone Analysis Software (qSAS) to obtain total stone volume (TSV), maximum diameter (MD) and stone number. Rate of dissolution using total stone volume was calculated over the treatment period.
resultsTwenty-seven patients were started on oral dissolution therapy, corrected for renal function. After mean duration of 180 days (range 41-531), 16 patients failed treatment resulting in surgical therapy. Twenty stones in 11 patients showed complete or partial dissolution. Compared to those who failed treatment, patients with complete or partial dissolution had lower 24 h urinary uric acid and higher treatment urine pH. Thirteen (65%) stones showed complete dissolution after a mean 167.6 days. Rate of change for responders was 4.73 mm DISCUSSION/
conclusionsSoftware-calculated total stone volume may be an effective method of measuring uric acid stone response to oral alkalization therapy. Stone volume decreased by 50% after 12.3 weeks of treatment and could be an important benchmark for oral dissolution therapyoral dissolution therapy. Further studies with a larger sample and validation of the software are needed to confirm if this can be used to guide surveillance schedules for dissolution therapy.
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