Observational studyInfection2021
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study.
Observational study in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Preparing for pandemics: a systematic review of pandemic influenza clinical management guidelines.BMC medicine · 2022Pooled it
- Epidemiology and clinical evolution of non-multisystem inflammatory syndrome (MIS-C) dermatological lesions in pediatric patients affected by SARS-CoV-2 infection: A systematic review of the literature.European journal of pediatrics · 2022Pooled it
- Clinical features of COVID-19 for integration of COVID-19 into influenza surveillance: A systematic review.Journal of global health · 2022Pooled it
- RETRACTED: Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022Trial
- Health-related quality of life in COVID-19 in the United Kingdom: a vignette study.Health economics review · 2026Article
- Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients.Intensive care medicine experimental · 2026Article
- How to conduct an individual participant data meta-analysis in response to an emerging pathogen: Lessons learned from Zika and COVID-19.Research synthesis methods · 2026Review
- Outcomes and Impact of Pre-ECMO Clinical Course in Severe COVID-19-Related ARDS Treated with VV-ECMO: Data from an Italian Referral ECMO Center.Journal of clinical medicine · 2024Article
- Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms.Heliyon · 2024Article
- Association of Inflammatory Mediators with Mitochondrial DNA Variants in Geriatric COVID-19 Patients.Aging and disease · 2024Article
- A Retrospective Study on COVID-19 Infections Caused by Omicron Variant with Clinical, Epidemiological, and Viral Load Evaluations in Breakthrough Infections.International journal of medical sciences · 2024Article
- Atypical Presentation of COVID-19 in Older Adults: A Scoping Review.Portuguese journal of public health · 2023Article
- Symptoms, symptom severity, and contact with primary health care among nonhospitalized COVID-19 patients: a Norwegian web-based survey.Scandinavian journal of primary health care · 2023Article
- Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry.Research and practice in thrombosis and haemostasis · 2023Article
- Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study.Scientific reports · 2023Observational
- Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19.International journal of epidemiology · 2023Article
- COVID-19 (Omicron strain) hospital admissions from a virtual ward - who required further care?Influenza and other respiratory viruses · 2023Observational
- Risk factors and outcomes of delirium in hospitalized older adults with COVID-19: A systematic review and meta-analysis.Aging and health research · 2023Review
- COVID-19 and pediatric pulmonology: Feedback from an expert center after the first year of the pandemic.Pediatric pulmonology · 2023Review
- Non-Typical Clinical Presentation of COVID-19 Patients in Association with Disease Severity and Length of Hospital Stay.Journal of personalized medicine · 2023Article
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Abstract
backgroundThe ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
methodsInternational, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
results'Typical' symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
interpretationThis international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.
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