Evidence map›Paper›PMID 34170449›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2021

Mutations of the VCORC1 Gene of Resistance to Anticoagulants in Synanthropic Rodents in Urbanized Areas of Russia.

A N Maltsev, S V Ryabov, V V Stakheev, N V Panasjuk, S N Gashev, N V Sorokina, Y A Bazhenov, E V Kotenkova

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

A N MaltsevSevertsov Institute of Problems of Ecology and Evolution, Russian Academy of Sciences, 119071, Moscow, Russia. mus-musculus@yandex.ru.
S V RyabovResearch Institute of Disinfectology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 117246, Moscow, Russia.
V V StakheevSouthern Research Center, Russian Academy of Sciences, 344006, Rostov-on-Don, Russia.
N V PanasjukSouthern Research Center, Russian Academy of Sciences, 344006, Rostov-on-Don, Russia.
S N GashevUniversity of Tyumen, 625003, Tyumen, Russia.
N V SorokinaUniversity of Tyumen, 625003, Tyumen, Russia.
Y A BazhenovInstitute of Natural Resources, Ecology and Cryology, Siberian Branch, Russian Academy of Sciences, 672090, Chita, Russia.
E V KotenkovaSevertsov Institute of Problems of Ecology and Evolution, Russian Academy of Sciences, 119071, Moscow, Russia.
Severtsov Institute of Ecology and Evolution · RUUniversity of Tyumen · RUFederal Service for Surveillance on Consumer Rights Protection and Human Wellbeing · RUInstitute of Natural Resources, Ecology and Cryology · RURussian Academy of Sciences · RUSouthern Scientific Center · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This is the first study to analyze the variability of two exons (the 1st and 3rd) of the VCORC1 gene in Russian populations of mice and rats, namely, 125 Mus musculus and 19 Rattus norvegicus captured in 13 settlements. Previously, it has been shown that a number of mutations in these exons in the countries of Western Europe are associated with resistance to anticoagulants in synanthropic rodents. We did not find such mutations in house mice in Russia. However, in the first exon, two previously unknown mutations were identified that could potentially have such an effect (Lys58Arg and Ser31Trp). In three districts of Moscow, Norway rats were found carrying in the third exon a previously known resistance mutation (Tyr139Ser) in the heterozygous state. The results are discussed in connection with the intensity of the use of anticoagulants in the settlements of Russia and the mutation rate of the VCORC1 gene.

Indexed as

AnticoagulantsRodentiaAnimalsEuropeMiceMutationRatsRussiaAnticoagulantsMus musculusresistance to anticoagulantsRuttus norvegicusVCORC1

Identifiers

PMID34170449
OpenAlexW3174469425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.