ArticlePediatric nephrology (Berlin, Germany)2022
Discordances between pediatric and adult thresholds in the diagnosis of hypertension in adolescents with CKD.
Article in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Beyond genetics: how environmental stressors drive pediatric hypertension risk.Pediatric nephrology (Berlin, Germany) · 2026Review
- Australian Guideline for the Identification and Management of Hypertension in Children and Adolescents.Journal of paediatrics and child health · 2026Article
- Impact of the 2022 ambulatory blood pressure monitoring guidelines on blood pressure phenotypes in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2026Article
- Hypertension and Cardiovascular Risk Among Children with Chronic Kidney Disease.Current hypertension reports · 2024Review
- Changes in Prevalence and Phenotype of Hypertension in Children Suspected of Hypertension Using the 2022 American Heart Association Guidelines.Global pediatric health · 2024Article
- Relevant detection indicator of prethrombotic state in patients with primary hypertension.World journal of clinical cases · 2023Article
- Impact of the 2022 American Heart Association pediatric ambulatory blood pressure monitoring statement on the diagnosis of hypertension.Pediatric nephrology (Berlin, Germany) · 2023Article
- Does the Body Mass Index Category Influence Ambulatory Blood Pressure Parameters in Office Normotensive Obese Children?Pediatric cardiology · 2023Article
- Pediatric Ambulatory Blood Pressure Classification: The Case for a Change.Hypertension (Dallas, Tex. : 1979) · 2021Review
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundAdolescents with chronic kidney disease (CKD) are a unique population with a high prevalence of hypertension. Management of hypertension during the transition from adolescence to adulthood can be challenging given differences in normative blood pressure values in adolescents compared with adults.
methodsIn this retrospective analysis of the Chronic Kidney Disease in Children Cohort Study, we compared pediatric versus adult definitions of ambulatory- and clinic-diagnosed hypertension in their ability to discriminate risk for left ventricular hypertrophy (LVH) and kidney failure using logistic and Cox models, respectively.
resultsOverall, among 363 adolescents included for study, the prevalence of systolic hypertension was 27%, 44%, 12%, and 9% based on pediatric ambulatory, adult ambulatory, pediatric clinic, and adult clinic definitions, respectively. All definitions of hypertension were statistically significantly associated with LVH except for the adult ambulatory definition. Presence of ambulatory hypertension was associated with 2.6 times higher odds of LVH using pediatric definitions (95% CI 1.4-5.1) compared to 1.4 times higher odds using adult definitions (95% CI 0.8-3.0). The c-statistics for discrimination of LVH was statistically significantly higher for the pediatric definition of ambulatory hypertension (c=0.61) compared to the adult ambulatory definition (c=0.54), and the Akaike Information Criterion was lower for the pediatric definition. All definitions were associated with progression to kidney failure.
conclusionOverall, there was not a substantial difference in pediatric versus adult definitions of hypertension in predicting kidney outcomes, but there was slightly better risk discrimination of the risk of LVH with the pediatric definition of ambulatory hypertension.
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