ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2021
Sleep duration as an independent factor associated with vitamin D levels in the EPISONO cohort.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Lifestyle in flux: urbanization, dietary shifts, and endocrine health in emerging adulthood.Reproductive biology and endocrinology : RB&E · 2025Article
- Associations Among Sleep Duration, Physical Activity, and Nutrient Intake in Korean Adults.Nutrients · 2025Article
- Effect of CPAP therapy on vitamin D status in patients with obstructive sleep apnea and chronic obstructive pulmonary disease overlap syndrome.Sleep & breathing = Schlaf & Atmung · 2025Article
- Do not sleep on vitamin D: vitamin D is associated with sleep variability in apparently healthy adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Association Between Serum Vitamin D Levels and Periodontal Conditions According to Sleep Duration Using Data from Korea National Health and Nutrition Examination Survey.Oral health & preventive dentistry · 2024Article
- Obstructive sleep apnea and vitamin D level: Has the dust settled?The clinical respiratory journal · 2024Review
- Nocturnal sleep duration and bone mineral density: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES) 2007-2014.BMC endocrine disorders · 2022Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesObstructive sleep apnea and short sleep duration have been separately associated with inadequate serum 25-hydroxyvitamin D [25(OH)D] levels. However, whether these 2 factors may concurrently influence 25(OH)D in the general population is unknown. We hypothesized that both obstructive sleep apnea and short sleep duration would be independently associated with lower concentrations of 25(OH)D in a sex-dependent manner.
methodsIn this cross-sectional study, 712 individuals, part of the prospective EPISONO cohort (Brazil), underwent polysomnography, answered sleep questionnaires, and had their blood collected for serum 25(OH)D quantification.
resultsIndividuals with a sleep duration of < 6 hours had 2-fold increased odds of 25(OH)D < 20 ng/mL compared with those who reported 6 or more hours of sleep, even after adjusting for confounding factors. Subset sex analysis revealed that men with a sleep duration of < 6 hours had 4-fold increased odds of 25(OH)D < 20 ng/mL. In women, short sleep duration was not associated with lower 25(OH)D levels. The presence of obstructive sleep apnea (as classified according to the individual's apnea-hypopnea index) was not independently related to 25(OH)D concentrations in men or women. Sleep parameters, including sleep latency and sleep efficiency, had no association with 25(OH)D < 20 ng/mL.
conclusionsShort sleep, but not apnea-hypopnea index, was an independent factor associated with low 25(OH)D serum levels in men, but not in women. Apnea-hypopnea index scores were not associated with 25(OH)D levels in either sex. These results raise the possibility of investigating sex-specific characteristics, such as gonadal hormone regulation, and re-evaluating obstructive events by classifying them in mild, moderate, and severe obstructive sleep apnea. CITATION: de Oliveira DL, Dokkedal-Silva V, Fernandes GL, Kim LJ, Tufik S, Andersen ML. Sleep duration as an independent factor associated with vitamin D levels in the EPISONO cohort.
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