Evidence map›Paper›PMID 34170009›Full record

ArticleJournal of cellular physiology2021

Glial-derived neurotrophic factor in human airway smooth muscle.

Sangeeta Bhallamudi, Benjamin B Roos, Jacob J Teske, Sarah A Wicher, Andrea McConico, Christina M Pabelick, Venkatachalem Sathish, Y S Prakash

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Downregulation of protein phosphatase 2Aα in asthmatic airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  4. Functional role of glial-derived neurotrophic factor in a mixed allergen murine model of asthma.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  5. Article
  6. Sputum Neurturin Levels in Adult Asthmatic Subjects.Journal of asthma and allergy · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sangeeta BhallamudiDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota, USA.
Benjamin B RoosDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Jacob J TeskeDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-3361-5859
Sarah A WicherDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Andrea McConicoDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota, USA.
Christina M PabelickDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-4632-2174
Venkatachalem SathishDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota, USA.ORCID 0000-0001-9770-8299
Y S PrakashDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-2968-224X
Mayo Clinic · USNorth Dakota State University · US

Funding

Neurotrophins in the LungR01HL088029 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 2009 to 2022
$5.9M
Kisspeptins in the AirwayR01HL146705 · NHLBI · NORTH DAKOTA STATE UNIVERSITY · PI VENKATACHALEM, SATHISH · 2020 to 2024
$2.2M
Nicotine, Airway Smooth Muscle and AsthmaR01HL142061 · NHLBI · MAYO CLINIC ROCHESTER · PI PABELICK, CHRISTINA MARIA, PRAKASH, Y. S. · 2019 to 2022
$2.0M
NHLBI NIH HHS R01 HL088029NHLBI NIH HHS R01 HL142061NHLBI NIH HHS R01 HL146705
6 · The paper itself

Abstract

Airway smooth muscle (ASM) cells modulate the local airway milieu via production of inflammatory mediators and growth factors including classical neurotrophins, such as brain-derived neurotrophic factor (BDNF). The glial cell-derived neurotrophic factor (GDNF) family of ligands (GFLs) are nonclassical neurotrophins and their role in the airway is barely understood. The major GFLs, GDNF and Neurturin (NRTN) bind to GDNF family receptor (GFR) α1 and α2 respectively that pair with Ret receptor to accomplish signaling. In this study, we found GDNF is expressed in human lung and increased in adult asthma, while human ASM expresses GDNF and its receptors. Accordingly, we used human ASM cells to test the hypothesis that ASM expression and autocrine signaling by GFLs regulate [Ca

Indexed as

AsthmaGlial Cell Line-Derived Neurotrophic FactorGlial Cell Line-Derived Neurotrophic Factor ReceptorsHumansMuscle, SmoothMyocytes, Smooth MuscleNeurturinRespiratory SystemGDNF protein, humanGlial Cell Line-Derived Neurotrophic FactorGlial Cell Line-Derived Neurotrophic Factor ReceptorsNeurturinNRTN protein, humanairwayasthmacalciumneurotrophinRet receptor

Identifiers

PMID34170009
PMCPMC8671171
OpenAlexW3175835630

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.