Evidence map›Paper›PMID 34169762›Full record

ArticleTechnology in cancer research & treatment

Assessing Genetic Variants in Matched Biocompartments From Patients With Serous Ovarian Cancer.

Brooke E Sanders, Lisa Ku, Paul Walker, Benjamin G Bitler

Open access · goldAbstract read
In one paragraph

Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Brooke E SandersDivision of Gynecologic Oncology, Department of Obstetrics & Gynecology, The University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-7573-1460
Lisa KuDivision of Oncology, Department of Medicine, The University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Paul WalkerCirculogene, Birmingham, AL, USA.
Benjamin G BitlerUniversity of Colorado Comprehensive Cancer Center, Aurora, CO, USA.ORCID 0000-0002-5809-5271
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Cancer Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Targeting Wnt signaling to overcome PARP inhibitor resistance in ovarian cancerR00CA194318 · NCI · UNIVERSITY OF COLORADO DENVER · PI BITLER, BENJAMIN G · 2017 to 2019
$745k
NCI NIH HHS P30 CA046934NCI NIH HHS R00 CA194318
6 · The paper itself

Abstract

The clinical use of molecular tumor profiling (MTP) is expanding and there is an increasing use of MTP data to manage patient care. At the University of Colorado, 18 patients were diagnosed with primary serous ovarian cancer between 9/2015 and 6/2019 and consented for banking and analysis of tumor, ascites and plasma. All 18 patients had tumor and plasma samples that were sent for MTP, and 13 of 18 patients additionally had ascites collected and sent for MTP. 50-gene panel testing and BRCA testing were performed on primary tumor. BRCA genetic variants were more likely to be identified in plasma as compared to ascites or tumor, though not statistically significant (

Indexed as

AgedAged, 80 and overAscitesBRCA1 ProteinBRCA2 ProteinFemaleGene FrequencyGenetic TestingGerm-Line MutationHumansMiddle AgedNeoplasms, Cystic, Mucinous, and SerousOvarian NeoplasmsSequence Analysis, DNATumor Suppressor Protein p53Vascular Endothelial Growth Factor Receptor-2BRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanKDR protein, humanTP53 protein, humanTumor Suppressor Protein p53Vascular Endothelial Growth Factor Receptor-2ascitesgenetic variantovarian cancerplasmatumor heterogeneity

Identifiers

PMID34169762
PMCPMC8246573
OpenAlexW3175992975

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.