Evidence map›Paper›PMID 34169687›Full record

ReviewThe world journal of men's health2022

Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training.

Ashok Agarwal, Rakesh Sharma, Sajal Gupta, Renata Finelli, Neel Parekh, Manesh Kumar Panner Selvam, Ralf Henkel, Damayanthi Durairajanayagam, Camila Pompeu, Sarah Madani and 31 more

Open access · diamondAbstract readReview
In one paragraph

Review in The world journal of men's health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Semen Characteristics and Embryo Outcomes in IVF.Journal of family & reproductive health · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Is it Permissible to use Human Eggs inAsian bioethics review · 2025
    Article
  7. Article
  8. Article
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  10. Article
  11. Effects of cactus (Animal reproduction · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 19 countries.

Ashok AgarwalAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA. agarwaa@ccf.org.ORCID https://orcid.org/0000-0003-0585-1026
Rakesh SharmaAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-9664-6978
Sajal GuptaAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0001-6487-9681
Renata FinelliAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-5926-6407
Neel ParekhAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-6218-9254
Manesh Kumar Panner SelvamAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-9120-2278
Ralf HenkelAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0003-1128-2982
Damayanthi DurairajanayagamDepartment of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia.ORCID https://orcid.org/0000-0001-9049-0215
Camila PompeuInstituto Ideia Fèrtil, Santo Andrè, Brazil.ORCID https://orcid.org/0000-0002-7111-9477
Sarah MadaniDepartment of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Science and Technnology, Houari Boumedien, Algiers, Algeria.ORCID https://orcid.org/0000-0002-0887-0129
Andrea BeloHuntington Centro de Medicina Reproditiva S/A, Sao Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5472-400X
Neha SinghNOVA IVF, Gorakhpur, India.ORCID https://orcid.org/0000-0002-7151-0273
Simryn CovarrubiasDepartment of Physiology, University of San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-9792-7587
Sara DarbandiFetal Health Research Center, Hope Generation Foundation, Tehran, Iran.ORCID https://orcid.org/0000-0002-1868-6712
Raha SadeghiDepartment of Physiology, University of San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-6311-8706
Mahsa DarbandiFetal Health Research Center, Hope Generation Foundation, Tehran, Iran.ORCID https://orcid.org/0000-0002-2243-9319
Paraskevi VogiatziAndromed Health & Reproduction, Fertility Diagnostics Laboratory, Maroussi, Athens, Greece.ORCID https://orcid.org/0000-0001-9971-1619
Florence BoitrelleReproductive Biology, Fertility Preservation, Andrology, CECOS, Poissy Hospital, Poissy, France.ORCID https://orcid.org/0000-0002-5322-0141
Mara SimopoulouDepartment of Experimental Physiology, School of Health Sciences, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-1000-9100
Ramadan SalehDepartment of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.ORCID https://orcid.org/0000-0003-0503-3533
Mohamed ArafaAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0003-0107-8857
Ahmad MajzoubAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0001-7423-6241
Hussein KandilFakih IVF Fertility Center, Abu Dhabi, UAE.ORCID https://orcid.org/0000-0002-5549-3274
Armand ZiniDepartment of Surgery, McGill University, Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-2194-5578
Edmund KoDepartment of Urology, Loma Linda University Health, Loma Linda, CA, USA.ORCID https://orcid.org/0000-0002-7465-3616
Juan G AlvarezCentro ANDROGEN, La Coruña, Spain.ORCID https://orcid.org/0000-0002-4851-9579
Marlon MartinezSection of Urology, University of Santo Tomas Hospital, Manila, Philippines.ORCID https://orcid.org/0000-0002-1191-8154
Jonathan RamsayDepartment of Andrology, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0002-2403-7698
Sunil JindalDepartment of Andrology and Reproductive Medicine, Jindal Hospital, Meerut, India.ORCID https://orcid.org/0000-0002-8088-8710
Gian Maria BusettoDepartment of Urology and Renal Transplantation, University of Foggia Policlinico Riuniti of Foggia, Foggia, Italy.ORCID https://orcid.org/0000-0002-7291-0316
Hassan SallamDepartment of Obstetrics and Gynaecology, Alexandria University Faculty of Medicine, Alexandria, Egypt.ORCID https://orcid.org/0000-0003-1308-6280
Israel MaldonadoCitmer Reproductive Medicine, IVF LAB, Mexico City, Mexico.ORCID https://orcid.org/0000-0003-2765-6176
Christina AnagnostopoulouIVF Clinic "Akeso-Embryo ART", Athens, Greece.ORCID https://orcid.org/0000-0003-0999-6484
Marco G AlvesDepartment of Anatomy, Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0001-7635-783X
Pallav SenguptaDepartment of Physiology, Faculty of Medicine, MAHSA University, Selangor, Malaysia.ORCID https://orcid.org/0000-0002-1928-5048
Kambiz GilanyReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.ORCID https://orcid.org/0000-0002-3620-0819
Donald P EvensonSCSA Diagnostics, Brookings, SD, USA.ORCID https://orcid.org/0000-0002-9085-0097
Sheena E M LewisQueens University Belfast, Belfast, Northern Ireland, UK.ORCID https://orcid.org/0000-0001-5665-1572
Jaime GosalvezGenetic Unit, Department of Biology, Universidad Autónoma de Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0003-3624-4261
Rafael F AmbarDepartment of Urology, Centro Universitario em Saude do ABC/Andrology Group at Ideia Fertil Institute of Human Reproduction, Santo André, Brazil.ORCID https://orcid.org/0000-0002-3496-2895
Rupin ShahDepartment of Urology, Lilavati Hospital and Research Centre, Mumbai, India.ORCID https://orcid.org/0000-0002-7868-5949
Cleveland Clinic · USUniversity of California, San Francisco · USAcademic Center for Education, Culture and Research · IRAlexandria University · EGCenter for Human Reproduction · USFaculdade de Medicina do ABC · BRHammersmith Hospital · GBHuntington University · USInformation Group on Reproductive Choice · MXInstituto Sapientia · BRIVI Middle East Fertility Clinic · AELETO Maternity Hospital · GRLilavati Hospital & Research Centre · INLoma Linda University · USMahsa University · MYMcGill University · CANational and Kapodistrian University of Athens · GRQueen's University Belfast · GBSohag University · EGTulane University · US

Funding

American Center for Reproductive Medicine
6 · The paper itself

Abstract

Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially sperm morphology assessment is very difficult to standardize and obtain reproducible results. This is mainly due to the highly subjective nature of their evaluation. ICSI is the choice of treatment when sperm morphology is severely abnormal (teratozoospermic). Hence, the standardization of laboratory protocols for sperm morphology evaluation represents a fundamental step to ensure reliable, accurate and consistent laboratory results that avoid misdiagnoses and inadequate treatment of the infertile patient. This article aims to promote standardized laboratory procedures for an accurate evaluation of sperm morphology, including the establishment of quality control and quality assurance policies. Additionally, the clinical importance of sperm morphology results in assisted reproductive outcomes is discussed, along with the clinical management of teratozoospermic patients.

Indexed as

Abnormality, teratozoospermiaMorphology, stainSperm

Identifiers

PMID34169687
PMCPMC9253798
OpenAlexW3175131791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.