ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2021
Flaxseed Effects on Inflammation Regulatory Gene Expressions in an Obese Animal Model.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Utilizing the healing power of flaxseed: a narrative review of its therapeutic applications.Journal of diabetes and metabolic disorders · 2025Review
- Anti-Oxidant and Anti-Cancer Properties of Flaxseed.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Obesity is known to be partially influenced by low-grade inflammation caused by pro-inflammatory cytokines and excess adipose tissue. Flaxseed contains secoisolariciresinol diglucoside (SDG) and α-linolenic acid (ALA) that have been shown to prevent pro-inflammatory cytokine production and secretion. This study determined flaxseed effects on inflammation regulatory gene expressions and their relationships with weight gain in an obese animal model. C57BL/6J mice were fed with whole flaxseed, defatted flaxseed, or flaxseed oil supplemented high-fat diet for eight weeks. After eight weeks of dietary treatment, NF-κB, IκBα, IKKβ, IL-6, TNF-α, Akt2, and adiponectin gene expressions were measured. The result shows how health-promoting compounds in flaxseed assist in alleviating and preventing obesity-induced low-grade inflammation by actively working against IKKβ/NF-κB pathway.
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Registered trials
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