Evidence map›Paper›PMID 34169411›Full record

ReviewStem cell reviews and reports2022

The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes for Orthopedic Diseases Treatment.

Kosar Malekpour, Ali Hazrati, Marziah Zahar, Alexander Markov, Angelina Olegovna Zekiy, Jamshid Gholizadeh Navashenaq, Leila Roshangar, Majid Ahmadi

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell reviews and reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

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  14. Hepatoprotective effect of hUC-MSC secretome in LPS-induced HepG2 cells.Iranian journal of basic medical sciences · 2026
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Kosar MalekpourDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Ali HazratiDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Marziah ZaharSocial Security Centre of Excellence, School of Business Management, College of Business, Universiti Utara Malaysia, Sintok Kedah, Malaysia.
Alexander MarkovTyumen State Medical University, Tyumen, Russia.
Angelina Olegovna ZekiyDepartment of Prosthetic Dentistry, Sechenov First Moscow State Medical University, Moscow, Russia.
Jamshid Gholizadeh NavashenaqNoncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran.
Leila RoshangarStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Majid AhmadiStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Ahmadi.m@tbzmed.ac.ir.ORCID 0000-0003-4787-5261
Tabriz University of Medical Sciences · IRTarbiat Modares University · IRBam University of Medical Sciences · IRNorthern University of Malaysia · MYSechenov University · RUTyumen State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Musculoskeletal disorders (MSDs) are conditions that can affect muscles, bones, and joints. These disorders are very painful and severely limit patients' mobility and are more common in the elderly. MSCs are multipotent stem cells isolated from embryonic (such as the umbilical cord) and mature sources (such as adipose tissue and bone marrow). These cells can differentiate into various cells such as osteoblasts, adipocytes, chondrocytes, NP-like cells, Etc. Due to MSC characteristics such as immunomodulatory properties, ability to migrate to the site of injury, recruitment of cells involved in repair, production of growth factors, and large amount production of extracellular vesicles, these cells have been used in many regenerative-related medicine studies. Also, MSCs produce different types of EVs, such as exosomes, to the extracellular environment. Exosomes reflect MSCs' characteristics and do not have cell therapy-associated problems because they are cell-free. These vesicles carry proteins, nucleic acids, and lipids to the host cell and change their function. This review focuses on MSCs and MSCs exosomes' role in repairing dense connective tissues such as tendons, cartilage, invertebrate disc, bone fracture, and osteoporosis treatment.

Indexed as

ExosomesMesenchymal Stem CellsMusculoskeletal DiseasesAgedHumansRegenerative MedicineUmbilical CordExosomesMSCsMSDsOrthopedic diseaseRegenerative medicine

Identifiers

PMID34169411
PMCPMC8224994
OpenAlexW3176826173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.