ArticleMetabolic brain disease2021
Pain-relieving effects of Lawsonia inermis on neuropathic pain induced by chronic constriction injury.
Article in Metabolic brain disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Protective effects of cedrol against transient global cerebral ischemia/reperfusion injury in rat.BMC complementary medicine and therapies · 2025Article
- Effect of dietary supplementation of Lawsonia inermis and Acacia nilotica extract on growth performance, intestinal histopathology, and antioxidant status of broiler chickens challenged with coccidiosis.BMC veterinary research · 2025Article
- Protective Effect of Carvacrol against Oxidative Damage in Aged Rats.Central nervous system agents in medicinal chemistry · 2025Article
- Anandamide as a Therapeutic Target for Alleviating Neuropathic Pain and Inflammation in Rat Models.Current neurovascular research · 2025Article
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- Chemogenetics Modulation of Electroacupuncture Analgesia in Mice Spared Nerve Injury-Induced Neuropathic Pain through TRPV1 Signaling Pathway.International journal of molecular sciences · 2024Article
- Medicinal Plants for the Treatment of Neuropathic Pain: A Review of Randomized Controlled Trials.Current pharmaceutical biotechnology · 2024Review
- Edible Herbal Medicines as an Alternative to Common Medication for Sleep Disorders: A Review Article.Current neuropharmacology · 2024Review
- The Neuroprotective Effects and Probable Mechanisms of Everolimus in a Rat Model of Intracerebral Hemorrhage.Cellular and molecular neurobiology · 2023Article
- Stem cell therapy combined with luteolin alleviates experimental neuropathy.Metabolic brain disease · 2023Article
- Synergistic effect of ellagic acid and gabapentin in a rat model of neuropathic pain.Metabolic brain disease · 2023Article
- Effects of Capparis Spinosa extract on the neuropathic pain induced by chronic constriction injury in rats.Metabolic brain disease · 2022Article
- Synergistic Antimicrobial Effect ofInfection and drug resistance · 2022Article
- Neuroprotective effect of herniarin following transient focal cerebral ischemia in rats.Metabolic brain disease · 2021Article
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- Wound-Healing Properties of Henna in Pilonidal Sinus Surgery: A Randomized Study.Indian journal of dermatologyArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine the role of Lawsonia inermis (L. inermis) extract in the chronic constriction injury (CCI)-induced neuropathic pain. Following CCI surgery, L. inermis extract (250 mg/kg and 500 mg/kg) and gabapentin (100 mg/kg) were administered intraperitoneally for 14 consecutive days. Heat hyperalgesia and allodynia were assessed by radiant heat, aceton drop, and von frey filament tests, respectively. Rat pain behaviors were evaluated on -1sh, 3rd, 5th, 7th, 10th and 14th days post CCI surgery. At the end of the study, the spinal levels of malondialdehyde (MDA), total thiol, IL1-β, and TNF-α were estimated. Treatment of L. inermis extract reversed the decreased level of thiol and the elevation of MDA level in the spinal cord of CCI rats. Besides, L. inermis extract treatment decreased the elevation of inflammatory markers including IL1-β, and TNF-α in the spinal cord of CCI rats. These results indicated that L. inermis has potential neuroprotective effects against CCI induced neuropathic pain due to its anti-oxidant, and anti-inflammatory effects.
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Registered trials
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