ArticleJournal of assisted reproduction and genetics2021
Developmental potential of immature human oocytes aspirated after controlled ovarian stimulation.
Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessing the developmental competence of oocytes matured following rescue in vitro maturation: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2024Pooled it
- Antioxidant Supplementation with Caffeine During Rescue In Vitro Maturation Improves Fertilization and Embryo Development in Women of Advanced Maternal Age.Antioxidants (Basel, Switzerland) · 2026Article
- Rates and risk factors of oocyte immaturity: toward personalized selection for rescue in vitro maturation.Journal of assisted reproduction and genetics · 2026Article
- Treatment of human oocytes with extracellular vesicles from follicular fluid during rescueHuman reproduction open · 2026Article
- Mitochondrial dysfunction in oocytes: implications for fertility and ageing.Journal of ovarian research · 2025Review
- Ambient temperature transport of human oocytes: an unexpected research resource.Journal of assisted reproduction and genetics · 2025Article
- Oocyte maturation defect in women undergoing IVF: contributing factors and effects on mature sibling oocyte outcomes.Journal of assisted reproduction and genetics · 2025Article
- In Vitro Maturation and Time-Lapse Imaging of Immature Human Oocytes: A Direction Toward Clinical Applications.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Stereological study of organelle distribution in human mature oocytes.Scientific reports · 2024Article
- Histories and mysteries underlying meiotic maturation failure in human oocytes.Journal of assisted reproduction and genetics · 2024Article
- The developmental competence of human metaphase I oocytes with delayed maturation in vitro.Fertility and sterility · 2023Article
- The spectrum ofFrontiers in endocrinology · 2023Review
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntracytoplasmic sperm injection (ICSI) for initially immature oocytes that mature in vitro is controversial and practice varies widely. While it may increase the number of usable embryos, it may also be time-intensive and potentially low-yield. This study sought to elucidate which patients may benefit from ICSI of initially immature oocytes that matured in vitro.
methodsA retrospective study comparing fertilization, cleavage, blastulation, and embryo usage rates between sibling initially immature and mature oocytes that underwent ICSI between 2015 and 2019 was performed. Outcomes of initially immature oocytes were stratified by initial maturation stage, timing of progression to metaphase II (MII) in vitro, percentage of mature oocytes in the cycle, and female age.
resultsTen thousand eight hundred seventeen oocytes from 889 cycles were included. Of 3137 (29.0%) initially immature oocytes, 418 (13.3%) reached MII later on the day of retrieval (day 0) and 1493 (47.6%) on day 1. Overall, embryos originating from initially immature oocytes had lower cleavage and blastulation rates compared to those from initially mature oocytes (P<0.05, all groups). However, embryos from oocytes that matured later on day 0 comprised a unique subset that had clinically similar cleavage (75% vs 80%, RR 0.93, P=0.047) and blastulation rates (41% vs 50%, RR 0.81, P=0.024) compared to initially mature oocytes. Women with low percentages of mature oocytes in the cycle overall and women ≥40 in cleavage cycles derived the highest relative benefit from the use of immature oocytes.
conclusionICSI of immature oocytes, particularly those that mature later on the day of retrieval, may improve numbers of usable embryos. This study supports routine reassessment of immature oocytes for progression to MII and ICSI on day 0. An additional reassessment on day 1 may also be of use in older women or those with low percentage of mature oocytes.
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