ReviewMicrobial ecology2022
Bacteria and Methanogens in the Human Microbiome: a Review of Syntrophic Interactions.
Review in Microbial ecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Effect of Operational Parameters on the Cultivation of the Gut Microbiome in Continuous Bioreactors Inoculated with Feces: A Systematic Review.Journal of agricultural and food chemistry · 2023Pooled it
- Effects of 5-Hydroxymethylfurfural on In Vitro Rumen Fermentation Characteristics and Bacterial Community Structure of Diets with Different Concentrate-to-Roughage Ratios.Animals : an open access journal from MDPI · 2026Article
- Modeling the microbial contribution to human energy balance using the Digestion, Absorption, and Microbial Metabolism (DAMM) model.PloS one · 2026Article
- Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism.Gut microbes · 2025Article
- Hydrogen Sulfide and Methane on Breath Test Correlate with Human Small Intestinal Hydrogen Sulfide Producers and Methanogens.Digestive diseases and sciences · 2025Article
- Microbiome-based prediction of allogeneic hematopoietic stem cell transplantation outcome.Genome medicine · 2025Article
- Archaeal diversity in the microbiomes of four wild bird species.Microbiology spectrum · 2025Article
- Article
- Exploring the human archaeome: its relevance for health and disease, and its complex interplay with the human immune system.The FEBS journal · 2025Review
- Streptococcus abundance and oral site tropism in humans and non-human primates reflects host and lifestyle differences.NPJ biofilms and microbiomes · 2025Article
- Human Milk Archaea Associated with Neonatal Gut Colonization and Its Co-Occurrence with Bacteria.Microorganisms · 2025Article
- Effects of plant-based fermented broth on rumen fermentation, gastrointestinal development, and microbial populations in fattening lambs.Frontiers in veterinary science · 2025Article
- Domestic sewage as a sustainable freshwater substitute for enhanced anaerobic digestion of lignocellulosic biomass.Scientific reports · 2024Article
- The Role of Microbiota-Related Co-Metabolites in MASLD Progression: A Narrative Review.Current issues in molecular biology · 2024Review
- The oral microbiome: diversity, biogeography and human health.Nature reviews. Microbiology · 2024Review
- Simulated digestions of free oligosaccharides and mucin-type O-glycans reveal a potential role for Clostridium perfringens.Scientific reports · 2024Article
- Causal relationship between gut microbiota and constipation: a bidirectional Mendelian randomization study.Frontiers in microbiology · 2024Article
- Review
- Diabetes and gut microbiome.Frontiers in microbiology · 2024Review
- Evaluation of Tannin-Delivery Approaches for Gut Microbiota Modulation: Comparison of Pectin-Based Microcapsules and Unencapsulated Extracts.Journal of agricultural and food chemistry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Methanogens are microorganisms belonging to the Archaea domain and represent the primary source of biotic methane. Methanogens encode a series of enzymes which can convert secondary substrates into methane following three major methanogenesis pathways. Initially recognized as environmental microorganisms, methanogens have more recently been acknowledged as host-associated microorganisms after their detection and initial isolation in ruminants in the 1950s. Methanogens have also been co-detected with bacteria in various pathological situations, bringing their role as pathogens into question. Here, we review reported associations between methanogens and bacteria in physiological and pathological situations in order to understand the metabolic interactions explaining these associations. To do so, we describe the origin of the metabolites used for methanogenesis and highlight the central role of methanogens in the syntrophic process during carbon cycling. We then focus on the metabolic abilities of co-detected bacterial species described in the literature and infer from their genomes the probable mechanisms of their association with methanogens. The syntrophic interactions between bacteria and methanogens are paramount to gut homeostasis. Therefore, any dysbiosis affecting methanogens might impact human health. Thus, the monitoring of methanogens may be used as a bio-indicator of dysbiosis. Moreover, new therapeutic approaches can be developed based on their administration as probiotics. We thus insist on the importance of investigating methanogens in clinical microbiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.