Evidence map›Paper›PMID 34169328›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Effect of home-based prehabilitation in an enhanced recovery after surgery program for patients undergoing colorectal cancer surgery during the COVID-19 pandemic.

Francisco López-Rodríguez-Arias, Luis Sánchez-Guillén, Verónica Aranaz-Ostáriz, Daniel Triguero-Cánovas, Sandra Lario-Pérez, Xavier Barber-Valles, Francisco J Lacueva, José M Ramirez, Antonio Arroyo

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03618329 (Effect of Prehabilitation on the Lean Mass Index), which is not on this map. Cited by 43 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 20 pooled it
4.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03618329 naunknown statusnot on this map

Effect of Prehabilitation on the Lean Mass Index (IMM) in Patients Operated on for Colon Cancer in ERAS Programm.

TypeinterventionalSponsorFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat ValencianaRan2018 to 2019Enrolled130ConditionsColo-rectal Cancer, Nutrition DisordersArmsPrehabilitation
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 20 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Home-based multimodal prehabilitation before colorectal cancer surgery: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  11. Evaluating the therapeutic quality of prehabilitation programmes in patients scheduled for colorectal surgery: A systematic review and meta-analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025
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  12. Effect of home-based exercise prehabilitation on postoperative outcomes in colorectal cancer surgery: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Francisco López-Rodríguez-AriasDepartment of General Surgery, Colorectal Unit, Elche University Hospital, Miguel Hernández University, Carrer Almasara 11, 03203, Elche, Alicante, Spain.ORCID http://orcid.org/0000-0001-9786-2659
Luis Sánchez-GuillénDepartment of General Surgery, Colorectal Unit, Elche University Hospital, Miguel Hernández University, Carrer Almasara 11, 03203, Elche, Alicante, Spain. drsanchezguillen@gmail.com.ORCID http://orcid.org/0000-0003-0623-9074
Verónica Aranaz-OstárizDepartment of General Surgery, Colorectal Unit, Elche University Hospital, Miguel Hernández University, Carrer Almasara 11, 03203, Elche, Alicante, Spain.
Daniel Triguero-CánovasDepartment of General Surgery, Colorectal Unit, Elche University Hospital, Miguel Hernández University, Carrer Almasara 11, 03203, Elche, Alicante, Spain.
Sandra Lario-PérezDepartment of General Surgery, Colorectal Unit, Elche University Hospital, Miguel Hernández University, Carrer Almasara 11, 03203, Elche, Alicante, Spain.
Xavier Barber-VallesCenter for Operations Research, Miguel Hernández University, Elche, Alicante, Spain.
Francisco J LacuevaDepartment of General Surgery, Colorectal Unit, Elche University Hospital, Miguel Hernández University, Carrer Almasara 11, 03203, Elche, Alicante, Spain.
José M RamirezDepartment of General Surgery, Colorectal Unit, Lozano Blesa University Clinical Hospital, Zaragoza, Spain.
Antonio ArroyoDepartment of General Surgery, Colorectal Unit, Elche University Hospital, Miguel Hernández University, Carrer Almasara 11, 03203, Elche, Alicante, Spain.
Universitat de Miguel Hernández d'Elx · ESHospital Clínico Universitario Lozano Blesa · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgery remains the first curative treatment for colorectal cancer. Prehabilitation seems to attenuate the loss of lean mass in the early postoperative period. However, its long-term role has not been studied. Lockdown due to the COVID-19 pandemic has forced to carry out the prehabilitation program at home. This study aimed to assess the effect of home prehabilitation on body composition, complications, and hospital stay in patients undergoing oncological colorectal surgery.

methodsA prospective and randomized clinical study was conducted in 20 patients operated of colorectal cancer during COVID-19 lockdown (13 March to 21 June 2020) in a single university clinical hospital. Patients were randomized into two study groups (10 per group): prehabilitation vs standard care. Changes in lean mass and fat mass at 45 and 90 days after surgery were measured using multifrequency bioelectrical impedance analysis.

resultsPrehabilitation managed to reduce hospital stay (4.8 vs 7.2 days, p = 0.052) and postoperative complications (20% vs 50%, p = 0.16). Forty-five days after surgery, the loss of lean mass decreased (1.7% vs 7.1%, p = 0.17). These differences in lean mass were attenuated at 90 days; however, the standard care group increased considerably their fat mass compared to the prehabilitation group (+ 8.72% vs - 8.16%).

conclusionsHome prehabilitation has proven its effectiveness, achieving an attenuation of lean mass loss in the early postoperative period and a lower gain in fat mass in the late postoperative period. In addition, it has managed to reduce hospital stays and postoperative complications. REGISTRATION NUMBER: This article is part of an ongoing, randomized, and controlled clinical trial approved by the ethics committee of our hospital and registered in ClinicalTrials.gov in August 2018 with registration number NCT03618329.

Indexed as

Colorectal NeoplasmsCOVID-19Enhanced Recovery After SurgeryCommunicable Disease ControlHumansPandemicsPostoperative ComplicationsPreoperative CarePreoperative ExerciseProspective StudiesSARS-CoV-2Treatment OutcomeBody compositionConfinementCOVID-19Lean mass and fat massPrehabilitation

Identifiers

PMID34169328
PMCPMC8225311
OpenAlexW3172592087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.