ArticleHuman molecular genetics2021
Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth.
Article in Human molecular genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Tryptophan-Kynurenine Pathway Metabolites in Women Undergoing Caesarean Delivery.Life (Basel, Switzerland) · 2026Article
- The placental tryptophan pathway across gestation: implications for pregnancy outcomes.Human reproduction update · 2026Review
- Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth.Communications medicine · 2026Article
- Tryptophan Metabolism in Neurodevelopment and Its Implications For Neurodevelopmental Disorders.Molecular neurobiology · 2025Review
- Article
- Impact of intraamniotic inflammation on tryptophan metabolism in the placenta-fetal brain axis in rats.Reproduction (Cambridge, England) · 2025Article
- High rates of placental inflammation among samples collected by the Multi-Omics for Mothers and Infants consortium.American journal of obstetrics and gynecology · 2025Article
- Comparative analysis of machine learning techniques in metabolomic-based preterm birth prediction.Computational and structural biotechnology journal · 2025Article
- The Placenta as the Main Source of Serotonin in Ontogenetic Dynamics: Inflammation-Induced Modulation of Placental Serotonin Can Be Prevented by Immunoglobulin Administration.International journal of molecular sciences · 2024Article
- Mapping prenatal predictors and neurobehavioral outcomes of an epigenetic marker of neonatal inflammation - A longitudinal population-based study.Brain, behavior, and immunity · 2024Article
- Review
- Placental Expression of Glucose and Zinc Transporters in Women with Gestational Diabetes.Journal of clinical medicine · 2024Article
- Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C†.Biology of reproduction · 2024Article
- Maternal Acylcarnitine Disruption as a Potential Predictor of Preterm Birth in Primigravida: A Preliminary Investigation.Nutrients · 2024Article
- Molecular pathways in placental-fetal development and disruption.Molecular and cellular endocrinology · 2024Review
- Metabolomic analysis of the human placenta reveals perturbations in amino acids, purine metabolites, and small organic acids in spontaneous preterm birth.EXCLI journal · 2024Article
- Identification of key metabolism-related genes and pathways in spontaneous preterm birth: combining bioinformatic analysis and machine learning.Frontiers in endocrinology · 2024Article
- Genetic variants associated with spontaneous preterm birth in women from India: a prospective cohort study.The Lancet regional health. Southeast Asia · 2023Article
- A Higher Abundance ofMicroorganisms · 2023Article
- Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous preterm birth is a serious medical condition responsible for substantial perinatal morbidity and mortality. Its phenotypic characteristics, preterm labor with intact membranes (PTL) and preterm premature rupture of the membranes (PPROM), are associated with significantly increased risks of neurological and behavioral alterations in childhood and later life. Recognizing the inflammatory milieu associated with PTL and PPROM, here, we examined expression signatures of placental tryptophan metabolism, an important pathway in prenatal brain development and immunotolerance. The study was performed in a well-characterized clinical cohort of healthy term pregnancies (n = 39) and 167 preterm deliveries (PTL, n = 38 and PPROM, n = 129). Within the preterm group, we then investigated potential mechanistic links between differential placental tryptophan pathway expression, preterm birth and both intra-amniotic markers (such as amniotic fluid interleukin-6) and maternal inflammatory markers (such as maternal serum C-reactive protein and white blood cell count). We show that preterm birth is associated with significant changes in placental tryptophan metabolism. Multifactorial analysis revealed similarities in expression patterns associated with multiple phenotypes of preterm delivery. Subsequent correlation computations and mediation analyses identified links between intra-amniotic and maternal inflammatory markers and placental serotonin and kynurenine pathways of tryptophan catabolism. Collectively, the findings suggest that a hostile inflammatory environment associated with preterm delivery underlies the mechanisms affecting placental endocrine/transport functions and may contribute to disruption of developmental programming of the fetal brain.
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