Evidence map›Paper›PMID 34169243›Full record

ArticleiScience2021

A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system.

Duomeng Yang, Tao Lin, Cen Li, Andrew G Harrison, Tingting Geng, Penghua Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Duomeng YangDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
Tao LinDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
Cen LiDepartment of Microbiology & Immunology, School of Medicine, New York Medical College, Valhalla, NY 10595, USA.
Andrew G HarrisonDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
Tingting GengDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
Penghua WangDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
UConn Health · USNew York Medical College · US

Funding

The role of UBXNs in antiviral immunityR01AI132526 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WANG, PENGHUA · 2018 to 2022
$2.1M
NIAID NIH HHS R01 AI132526
6 · The paper itself

Abstract

Macrophage scavenger receptor 1 (MSR1) plays an important role in host defense to bacterial infections, M2 macrophage polarization, and lipid homeostasis. However, its physiological function in viral pathogenesis remains poorly defined. Herein, we report that MSR1 facilitates vesicular stomatitis virus (VSV) infection in the central nervous system. Msr1-deficient (

Indexed as

Cell biologyMolecular physiologyNeuroscienceVirology

Identifiers

PMID34169243
PMCPMC8208900
OpenAlexW3169561276

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.