Evidence map›Paper›PMID 34169156›Full record

ArticleBiochemistry and biophysics reports2021

Enhanced recombinant expression and purification of human IRAP for biochemical and crystallography studies.

Lufei Sui, Hwai-Chen Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lufei SuiDepartment of Biological Sciences, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA, 01854, USA.
Hwai-Chen GuoDepartment of Biological Sciences, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA, 01854, USA.
University of Massachusetts Lowell · US

Funding

Structural and Bioinformatics Analyses of M1 AminopeptidasesR15GM128152 · NIGMS · UNIVERSITY OF MASSACHUSETTS LOWELL · PI GUO, HWAI-CHEN · 2018 to 2022
$916k
NIGMS NIH HHS R15 GM128152
6 · The paper itself

Abstract

Insulin-regulated aminopeptidase (IRAP) in humans is a membrane bound enzyme that has multiple functions. It was first described as a companion protein of the insulin-responsive glucose transporter, Glut4, in specialized vesicles. The protein has subsequently been shown to be identical to the oxytocinase/aminopeptidase or the angiotensin IV (Ang IV) receptor (AT

Indexed as

Ang IV, angiotensin IVAT4, Ang IV receptorCognitive enhancersCrystallizationERAP, endoplasmic reticulum aminopeptidaseExpression and purificationIEX, ion exchange chromatographyIMAC, immobilized metal ion affinity chromatographyInsulin-regulated aminopeptidase (IRAP)IRAP, insulin-regulated aminopeptidaseL-AMC, leucine 7-amido-4-methylcoumarinLVV-H7, LVV-hemorphin-7MHC-I, major histocompatibility complex class IPeptide inhibitorSEC, size exclusion chromatographySubstrate affinity

Identifiers

PMID34169156
PMCPMC8207215
OpenAlexW3168740071

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.