ArticleJournal of clinical tuberculosis and other mycobacterial diseases2021
Central Nervous System Tuberculosis (CNS-TB) in treated HIV-infected adults in Tikur Anbessa Specialized Hospital, Ethiopia: A cross sectional study.
Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Pooled it
- Predictors of mortality in CNS tuberculosis: clinical and radiological parameters.BMC neurology · 2026Article
- Article
- Risk factors associated with post-tuberculosis sequelae: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCentral nervous system (CNS) tuberculosis (TB) is a calamitous infection with high rates of morbidity and mortality. Underlying HIV infection often increases susceptibility for acquiring TB and also complicates TB treatment. The study objectives were to assess the burden of CNS TB and associated factors in treatment experienced HIV infected adults.
methodsA single-center observational cross-sectional study was conducted between December 2019 and June 2020. Both descriptive and analytical statistics were used to analyze the data.
resultsNinety-five HIV infected adults with presumptive TB-HIV co-infection on combination antiretroviral therapy for median of 144 months were assessed. The mean age was 40.8 years (1SD = 12.4). Male to female ratio was 1:2. The prevalence of CNS tuberculosis was 56.8% (TB menigitis 53.7%, tuberculoma 2.1%, and spinal TB 1.1%). Patients with CNS TB were younger compared to those with extra CNS TB (38.6 vs. 43.6 years, p = 0.04). A higher proportion of patients with CNS TB had undetectable HIV RNA compared to those with extra CNS TB (55.8% vs. 36.8% p = 0.04). In multivariate regression analysis, advanced disease stages, deferred cotrimoxazole preventive therapy (CPT), and deferred INH preventive therapy (IPT) were found to be independent predictors of CNS TB. Although not statistically significant, the trend for HIV-associated cognitive decline was higher in the group with CNS TB.
conclusionThe prevalence of CNS TB was higher among HIV-infected adults with TB-HIV co-infection. TB meningitis was the most common type of CNS TB. Advanced disease stages, deferred CPT, and deferred IPT were predictors of CNS tuberculosis. Although statistically not-significant, the trend for HAND was higher in the group diagnosed with CNS tuberculosis.
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