Evidence map›Paper›PMID 34169145›Full record

ArticleChemistrySelect2019

Paired Spectroscopic and Crystallographic Studies of Proteases.

Meiqi Luo, Christopher N Eaton, Kenneth R Hess, Christine M Phillips-Piro, Scott H Brewer, Edward E Fenlon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistrySelect, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meiqi LuoDepartment of Chemistry, Franklin & Marshall College, PO Box 3003, Lancaster, PA 17604-3003.
Christopher N EatonDepartment of Chemistry, Franklin & Marshall College, PO Box 3003, Lancaster, PA 17604-3003.
Kenneth R HessDepartment of Chemistry, Franklin & Marshall College, PO Box 3003, Lancaster, PA 17604-3003.
Christine M Phillips-PiroDepartment of Chemistry, Franklin & Marshall College, PO Box 3003, Lancaster, PA 17604-3003.
Scott H BrewerDepartment of Chemistry, Franklin & Marshall College, PO Box 3003, Lancaster, PA 17604-3003.
Edward E FenlonDepartment of Chemistry, Franklin & Marshall College, PO Box 3003, Lancaster, PA 17604-3003.
Franklin & Marshall College · US

Funding

Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Use of Vibrational Reporters to Measure Dynamics and Distances in RNA and ProteinsR15GM093330 · NIGMS · FRANKLIN AND MARSHALL COLLEGE · PI BREWER, SCOTT H, FENLON, EDWARD EMMETT · 2010 to 2024
$1.3M
NIGMS NIH HHS P41 GM103403NIGMS NIH HHS R15 GM093330NIH HHS S10 OD021527
6 · The paper itself

Abstract

The active sites of subtilisin and trypsin have been studied by paired IR spectroscopic and X-ray crystallographic studies. The active site serines of the proteases were reacted with 4-cyanobenzenesulfonyl fluoride (CBSF), an inhibitor that contains a nitrile vibrational reporter. The nitrile stretch vibration of the water-soluble inhibitor model, potassium 4-cyanobenzenesulfonate (KCBSO), and the inhibitor were calibrated by IR solvent studies in H

Indexed as

crystallographyproteasesspectroscopyvibrational reporters

Identifiers

PMID34169145
PMCPMC8221577
OpenAlexW2971613367

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.