Evidence map›Paper›PMID 34169015›Full record

ArticleJournal of orthopaedic case reports2020

Marrying Tendon and Nerve Gliding Exercises with Hydrodissection Following Injection for Carpal Tunnel Syndrome - A New Treatment Approach?

Nathan J Savage, Joseph Albano

Registry-linked trialOpen access · greenAbstract readCase Reports
In one paragraph

Article in Journal of orthopaedic case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07281573 (The Effect of Exercises on the Shear Wave Velocity of the Median Nerve and the 3rd FDS in Patients With Carpal Tunnel Syndrome), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07281573 nacompletednot on this mapstarted 2025, after this paper: background citation

The Effect of Exercises on the Shear Wave Velocity of the Median Nerve and the 3rd FDS in Patients With Carpal Tunnel Syndrome

TypeinterventionalSponsorUniversity Medical Centre LjubljanaRan2025 to 2025Enrolled91ConditionsCarpal Tunnel Syndrome, Peripheral NeuropathiesArmsNerve and tendon gliding exercises and strength exercises
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Nathan J SavageDepartment of Physical Therapy, Total Rehab, Inc., South Ogden, UT, USA.
Joseph AlbanoAlbano Clinic, Salt Lake City, UT, USA.
AlbaNova · SETotal Rehab · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHydrodissection has been used during injection procedures to liberate median nerve from surrounding adhesions. This investigation examined clinical and neurophysiologic impact of ultrasound-guided injections in patient with bilateral carpal tunnel syndrome (CTS) serving as own control. Novel to this investigation was performance of active tendon and nerve gliding exercises following median nerve hydrodissection and injection. CASE REPORT: A 37-year-old male with 6-year history of bilateral CTS presented for treatment. Wrists randomly assigned to receive platelet-rich plasma (PRP) or equal volume saline injection and median nerve hydrodissection. The patient performed active tendon and nerve gliding exercises following injection procedures. Pain ratings, CTS-related disability scores, median nerve function, and median nerve cross-section area measurements for each wrist/hand collected at baseline 2, 4, 6, and 12 months following injection procedures. 6-month follow-up. The right (saline) and left (PRP) wrists showed improvements in disability and nerve function. The left wrist (PRP) also showed improvement in pain. 1-year follow-up. The right (saline followed by PRP at 6 months) and left (PRP) wrists showed improvements in pain, disability, and nerve function.

conclusionResults suggest innovative treatment approach for CTS, namely, ultrasound-guided PRP injection including median nerve hydrodissection followed by performance of active tendon and nerve gliding exercises in immediate post-injection period. The patient demonstrated improvements in pain, CTS-related disability, and median nerve function comparable to surgical release and generally better than non-surgical interventions. Findings should stimulate further investigation into marrying mechanically based treatments with PRP to produce better long-term outcomes in patients with CTS.

Indexed as

Electrodiagnosismedian neuropathyphysical therapyultrasonography

Identifiers

PMID34169015
PMCPMC8046441
OpenAlexW3173445618

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.