Evidence map›Paper›PMID 34168995›Full record

ArticleFrontiers in oncology2021

Can Smoking Cause Differences in Urine Microbiome in Male Patients With Bladder Cancer? A Retrospective Study.

Wenchao Ma, Wentao Zhang, Liliang Shen, Ji Liu, Fuhang Yang, Niraj Maskey, Hong Wang, Junfeng Zhang, Yang Yan, Xudong Yao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The Urinary Microbiota and the Gut-Bladder Axis in Bladder Cancer.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. BK Virus Infection and Risk Factors in Kidney Transplant Recipients.Journal of clinical practice and research · 2025
    Article
  11. The Urinary Microbiome in Health and Disease: Relevance for Bladder Cancer.International journal of molecular sciences · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Is the Urinary and Gut Microbiome Associated With Bladder Cancer?Clinical Medicine Insights. Oncology · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wenchao MaDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Wentao ZhangDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Liliang ShenDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Ji LiuDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Fuhang YangDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Niraj MaskeyDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Hong WangDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Junfeng ZhangDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Yang YanDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Xudong YaoDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Shanghai Tenth People's Hospital · CNTongji University · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTobacco smoking is a carcinogen for many cancers including bladder cancer. The microbiota is involved in the occurrence, development, and treatment of tumors. We explored the composition of male urinary microbiome and the correlation between tobacco smoking and microbiome in this study.

methodsAlpha diversity, principal component analysis (PCA) and Adonis analysis, linear discriminant analysis (LDA) coupled with effect size measurement, and PICRUSt function predictive analysis were used to compare different microbiome between smokers and non-smokers in men.

resultsThere were 26 qualified samples included in the study. Eleven of them are healthy controls, and the others are from men with bladder cancer. Simpson index and the result of PCA analysis between smokers and non-smokers were not different (P > 0.05) in healthy men. However, the abundance of Bacteroidaceae, Erysipelotrichales, Lachnospiraceae, Bacteroides, and so on in the urinary tract of smokers is much higher than that of non-smokers. Compared to non-smokers, the alpha diversity in smokers was elevated in patients with bladder cancer (P < 0.05). PCA analysis showed a significant difference between smokers and non-smokers (P < 0.001), indicating that tobacco smoking plays a vital role in urinary tract microbial composition.

conclusionThe composition of microbiome in the urinary tract is closely related to tobacco smoking. This phenomenon is more significant in patients with bladder cancer. This indicates tobacco smoking may promote the occurrence and development of bladder cancer by changing urinary tract microbiome.

Indexed as

bladder cancermalemicrobiomesmokeurine

Identifiers

PMID34168995
PMCPMC8217881
OpenAlexW3168538601

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.