ArticleBiomedical optics express2021
Disrupted signal variability of spontaneous neural activity in children with attention-deficit/hyperactivity disorder.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Immediate Effects of Acceptance and Commitment Therapy in Children with ADHD: A Pilot Resting-State fNIRS Study.Brain sciences · 2026Article
- Age-Related Changes in EEG Signal Complexity and Behavioral Variability from Childhood to Adulthood: A Multiscale Entropy Approach.Entropy (Basel, Switzerland) · 2026Article
- Comparing different motion correction approaches for resting-state functional connectivity analysis with functional near-infrared spectroscopy data.Neurophotonics · 2024Article
- Functional connectivity and complexity analyses of resting-state fMRI in pre-adolescents demonstrating the behavioral symptoms of ADHD.Psychiatry research · 2024Article
- Advances in the etiology and neuroimaging of children with attention deficit hyperactivity disorder.Frontiers in pediatrics · 2024Review
- Multiscale entropy of ADHD children during resting state condition.Cognitive neurodynamics · 2023Article
- Functional near-infrared spectroscopy in pediatric clinical research: Different pathophysiologies and promising clinical applications.Neurophotonics · 2023Article
- Can biomarkers be used to diagnose attention deficit hyperactivity disorder?Frontiers in psychiatry · 2023Review
- Article
- Age-related difference in muscle metabolism patterns during upper limb's encircling exercise: a near-infrared spectroscopy study.Biomedical optics express · 2022Article
- The potential shared brain functional alterations between adults with ADHD and children with ADHD co-occurred with disruptive behaviors.Child and adolescent psychiatry and mental health · 2022Article
- Prefrontal cortical connectivity and coupling of infraslow oscillation in the resting human brain: a 2-channel broadband NIRS study.Cerebral cortex communications · 2022Article
- Hemispheric Lateralization of Visuospatial Attention Is Independent of Language Production on Right-Handers: Evidence From Functional Near-Infrared Spectroscopy.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain signal variability (BSV) has shown to be powerful in characterizing human brain development and neuropsychiatric disorders. Multiscale entropy (MSE) is a novel method for quantifying the variability of brain signal, and helps elucidate complex dynamic pathological mechanisms in children with attention-deficit/hyperactivity disorder (ADHD). Here, multiple-channel resting-state functional near-infrared spectroscopy (fNIRS) imaging data were acquired from 42 children with ADHD and 41 healthy controls (HCs) and then BSV was calculated for each participant based on the MSE analysis. Compared with HCs, ADHD group exhibited reduced BSV in both high-order and primary brain functional networks, e.g., the default mode, frontoparietal, attention and visual networks. Intriguingly, the BSV aberrations negatively correlated with ADHD symptoms in the frontoparietal network and negatively correlated with reaction time variability in the frontoparietal, default mode, somatomotor and attention networks. This study demonstrates a wide alternation in the moment-to-moment variability of spontaneous brain signal in children with ADHD, and highlights the potential for using MSE metric as a disease biomarker.
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Registered trials
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