ArticleRoyal Society open science2021
Topological analysis of differential effects of ketamine and propofol anaesthesia on brain dynamics.
Article in Royal Society open science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Dreaming during anaesthesia: a scoping review.British journal of anaesthesia · 2026Article
- Charting higher-order models of brain function beyond pairwise interactions.Nature communications · 2026Article
- Neurogenic organ dysfunction syndrome after acute brain injury.Military Medical Research · 2025Review
- The topology of synergy: Linking topological and information-theoretic approaches to higher-order interactions in complex systems.PLoS computational biology · 2025Article
- Towards an expanded neurocognitive account of ketamine's rapid antidepressant effects.The international journal of neuropsychopharmacology · 2025Review
- Modelling low-dimensional interacting brain networks reveals organising principle in human cognition.Network neuroscience (Cambridge, Mass.) · 2025Article
- Nonlinear time series analysis of state-wise COVID-19 in Malaysia using wavelet and persistent homology.Scientific reports · 2024Article
- EEG spectral attractors identify a geometric core of brain dynamics.Patterns (New York, N.Y.) · 2024Article
- Psilocybin enhances insightfulness in meditation: a perspective on the global topology of brain imaging during meditation.Scientific reports · 2024Article
- Functional hierarchies in brain dynamics characterized by signal reversibility in ferret cortex.PLoS computational biology · 2024Article
- Unveiling the Connectivity of Complex Networks Using Ordinal Transition Methods.Entropy (Basel, Switzerland) · 2023Article
- The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states.Interface focus · 2023Article
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- Noise improves the association between effects of local stimulation and structural degree of brain networks.PLoS computational biology · 2023Article
- Multivariate information theory uncovers synergistic subsystems of the human cerebral cortex.Communications biology · 2023Article
- Mild cognitive impairment prediction and cognitive score regression in the elderly using EEG topological data analysis and machine learning with awareness assessed in affective reminiscent paradigm.Frontiers in aging neuroscience · 2023Article
- Machine learning approach for early onset dementia neurobiomarker using EEG network topology features.Frontiers in human neuroscience · 2023Article
- Article
- Flickering Emergences: The Question of Locality in Information-Theoretic Approaches to Emergence.Entropy (Basel, Switzerland) · 2022Article
- The complexity of the stream of consciousness.Communications biology · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Research has found that the vividness of conscious experience is related to brain dynamics. Despite both being anaesthetics, propofol and ketamine produce different subjective states: we explore the different effects of these two anaesthetics on the structure of dynamic attractors reconstructed from electrophysiological activity recorded from cerebral cortex of two macaques. We used two methods: the first embeds the recordings in a continuous high-dimensional manifold on which we use topological data analysis to infer the presence of higher-order dynamics. The second reconstruction, an ordinal partition network embedding, allows us to create a discrete state-transition network, which is amenable to information-theoretic analysis and contains rich information about state-transition dynamics. We find that the awake condition generally had the 'richest' structure, visiting the most states, the presence of pronounced higher-order structures, and the least deterministic dynamics. By contrast, the propofol condition had the most dissimilar dynamics, transitioning to a more impoverished, constrained, low-structure regime. The ketamine condition, interestingly, seemed to combine aspects of both: while it was generally less complex than the awake condition, it remained well above propofol in almost all measures. These results provide deeper and more comprehensive insights than what is typically gained by using point-measures of complexity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.