ArticleRoyal Society open science2021
Gene duplication and subsequent diversification strongly affect phenotypic evolvability and robustness.
Article in Royal Society open science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A simple model captures key characteristics of biological non-deterministic genotype-phenotype maps.PLoS computational biology · 2026Article
- Identification of Apple Flower Development-Related Gene Families and Analysis of Transcriptional Regulation.International journal of molecular sciences · 2024Article
- Transcriptome and genome-wide analysis of the potential role ofFrontiers in plant science · 2024Article
- Identification and Analysis of the Expression of theInternational journal of molecular sciences · 2023Article
- The non-deterministic genotype-phenotype map of RNA secondary structure.Journal of the Royal Society, Interface · 2023Article
- Genotype-phenotype mapping with polyominos made from DNA origami tiles.Biophysical journal · 2022Article
- Fast free-energy-based neutral set size estimates for the RNA genotype-phenotype map.Journal of the Royal Society, Interface · 2022Article
- Characterization of thePeerJ · 2022Article
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3 authors.
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Abstract
We study the effects of non-determinism and gene duplication on the structure of genotype-phenotype (GP) maps by introducing a non-deterministic version of the Polyomino self-assembly model. This model has previously been used in a variety of contexts to model the assembly and evolution of protein quaternary structure. Firstly, we show the limit of the current deterministic paradigm which leads to built-in anti-correlation between evolvability and robustness at the genotypic level. We develop a set of metrics to measure structural properties of GP maps in a non-deterministic setting and use them to evaluate the effects of gene duplication and subsequent diversification. Our generalized versions of evolvability and robustness exhibit positive correlation for a subset of genotypes. This positive correlation is only possible because non-deterministic phenotypes can contribute to both robustness and evolvability. Secondly, we show that duplication increases robustness and reduces evolvability initially, but that the subsequent diversification that duplication enables has a stronger, inverse effect, greatly increasing evolvability and reducing robustness relative to their original values.
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