Evidence map›Paper›PMID 34168788›Full record

ArticleChemical science2021

DNA-based constitutional dynamic networks as functional modules for logic gates and computing circuit operations.

Zhixin Zhou, Jianbang Wang, R D Levine, Francoise Remacle, Itamar Willner

Abstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. PhotocleavableChemical reviews · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhixin ZhouThe Institute of Chemistry, The Hebrew University of Jerusalem Jerusalem 91904 Israel Itamar.willner@mail.huji.ac.il.ORCID https://orcid.org/0000-0003-0450-1921
Jianbang WangThe Institute of Chemistry, The Hebrew University of Jerusalem Jerusalem 91904 Israel Itamar.willner@mail.huji.ac.il.
R D LevineThe Institute of Chemistry, The Hebrew University of Jerusalem Jerusalem 91904 Israel Itamar.willner@mail.huji.ac.il.
Francoise RemacleTheoretical Physical Chemistry, UR MolSys B6c, University of Liège B4000 Liège Belgium.
Itamar WillnerThe Institute of Chemistry, The Hebrew University of Jerusalem Jerusalem 91904 Israel Itamar.willner@mail.huji.ac.il.ORCID https://orcid.org/0000-0001-9710-9077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A nucleic acid-based constitutional dynamic network (CDN) is introduced as a single computational module that, in the presence of different sets of inputs, operates a variety of logic gates including a half adder, 2 : 1 multiplexer and 1 : 2 demultiplexer, a ternary multiplication matrix and a cascaded logic circuit. The CDN-based computational module leads to four logically equivalent outputs for each of the logic operations. Beyond the significance of the four logically equivalent outputs in establishing reliable and robust readout signals of the computational module, each of the outputs may be fanned out, in the presence of different inputs, to a set of different logic circuits. In addition, the ability to intercommunicate constitutional dynamic networks (CDNs) and to construct DNA-based CDNs of higher complexity provides versatile means to design computing circuits of enhanced complexity.

Identifiers

PMID34168788
PMCPMC8179666

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.