Evidence map›Paper›PMID 34168770›Full record

ArticleChemical science2021

Symmetry-related residues as promising hotspots for the evolution of

Jaeseung Yu, Jinsol Yang, Chaok Seok, Woon Ju Song

Abstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Protein Assembly by Design.Chemical reviews · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jaeseung YuDepartment of Chemistry, College of Natural Sciences, Seoul National University Seoul 08826 Republic of Korea woonjusong@snu.ac.kr.
Jinsol YangDepartment of Chemistry, College of Natural Sciences, Seoul National University Seoul 08826 Republic of Korea woonjusong@snu.ac.kr.
Chaok SeokDepartment of Chemistry, College of Natural Sciences, Seoul National University Seoul 08826 Republic of Korea woonjusong@snu.ac.kr.
Woon Ju SongDepartment of Chemistry, College of Natural Sciences, Seoul National University Seoul 08826 Republic of Korea woonjusong@snu.ac.kr.ORCID https://orcid.org/0000-0003-0434-2684

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Directed evolution has provided us with great opportunities and prospects in the synthesis of tailor-made proteins. It, however, often requires at least mid to high throughput screening, necessitating more effective strategies for laboratory evolution. We herein demonstrate that protein symmetry can be a versatile criterion for searching for promising hotspots for the directed evolution of

Identifiers

PMID34168770
PMCPMC8179601

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.