ArticleChemical science2021
Towards the rational design of ylide-substituted phosphines for gold(i)-catalysis: from inactive to ppm-level catalysis.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 44 citations in OpenAlex.
- Bridged Pyrroloindole-CAYC-Gold Complexes: Harnessing Weak Secondary Intramolecular Au···H-C(spAngewandte Chemie (International ed. in English) · 2026Article
- Gold(I) Complexes with Bulky Phosphanes: A Dual Approach to Triplet Harvesting and Hydroamination Catalysis.Inorganic chemistry · 2025Article
- Isolation of a Cyclic Trinuclear Gold(I) Complex with Metalated Phosphorus Ylides: Synthesis and Structural Properties.Inorganic chemistry · 2024Article
- Exploring Au(i) involving halogen bonding with N-heterocyclic carbene Au(i) aryl complexes in crystalline media.Chemical science · 2023Article
- From Stable PH-Ylides to α-Carbanionic Phosphines as Ligands for Zwitterionic Catalysts.Angewandte Chemie (International ed. in English) · 2022Article
- Au⋅⋅⋅H-C Hydrogen Bonds as Design Principle in Gold(I) Catalysis.Angewandte Chemie (International ed. in English) · 2021Article
- Ylide-Substituted Phosphines with a Cyclic Ylide-Backbone: Angle Dependence of the Donor Strength.Organometallics · 2021Article
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The implementation of gold catalysis into large-scale processes suffers from the fact that most reactions still require high catalyst loadings to achieve efficient catalysis thus making upscaling impractical. Here, we report systematic studies on the impact of the substituent in the backbone of ylide-substituted phosphines (YPhos) on the catalytic activity in the hydroamination of alkynes, which allowed us to increase the catalyst performance by orders of magnitude. While electronic changes of the ligand properties by introduction of aryl groups with electron-withdrawing or electron-donating groups had surprisingly little impact on the activity of the gold complexes, the use of bulky aryl groups with
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