Evidence map›Paper›PMID 34168743›Full record

ArticleChemical science2020

Engineering reversible cell-cell interactions using enzymatically lipidated chemically self-assembled nanorings.

Yiao Wang, Ozgun Kilic, Clifford M Csizmar, Sudhat Ashok, James L Hougland, Mark D Distefano, Carston R Wagner

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Synthetic Lipid Biology.Chemical reviews · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yiao WangDepartment of Chemistry, University of Minnesota Minneapolis Minnesota 55455 USA diste001@umn.edu wagne003@umn.edu.ORCID https://orcid.org/0000-0002-0229-5768
Ozgun KilicDepartment of Medicinal Chemistry, University of Minnesota Minneapolis Minnesota 55455 USA.ORCID https://orcid.org/0000-0001-6735-8830
Clifford M CsizmarDepartment of Medicinal Chemistry, University of Minnesota Minneapolis Minnesota 55455 USA.ORCID https://orcid.org/0000-0002-1221-8854
Sudhat AshokDepartment of Chemistry, Syracuse University Syracuse New York 13244 USA.ORCID https://orcid.org/0000-0001-6909-3151
James L HouglandDepartment of Chemistry, Syracuse University Syracuse New York 13244 USA.ORCID https://orcid.org/0000-0003-0444-1017
Mark D DistefanoDepartment of Chemistry, University of Minnesota Minneapolis Minnesota 55455 USA diste001@umn.edu wagne003@umn.edu.ORCID https://orcid.org/0000-0002-2872-0259
Carston R WagnerDepartment of Chemistry, University of Minnesota Minneapolis Minnesota 55455 USA diste001@umn.edu wagne003@umn.edu.ORCID https://orcid.org/0000-0001-7927-719X
University of Minnesota · USSyracuse University · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Targeting Effector Immune cells to Cancer with Chemically Self-Assembled Nanorings (CSANs)R01CA247681 · NCI · UNIVERSITY OF MINNESOTA · PI WAGNER, CARSTON R. · 2020 to 2024
$2.8M
Enzymatic Protein LabelingR01GM084152 · NIGMS · UNIVERSITY OF MINNESOTA · PI DISTEFANO, MARK D · 2010 to 2019
$2.6M
Determining the scope of prenylatable protein sequencesR01GM132606 · NIGMS · UNIVERSITY OF GEORGIA · PI KANNAN, NATARAJAN, SCHMIDT, WALTER K · 2019 to 2022
$1.6M
Engineering Cell-Cell Interactions by Chemically Self-Assembled CARSR21CA185627 · NCI · UNIVERSITY OF MINNESOTA · PI WAGNER, CARSTON R. · 2015 to 2016
$349k
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA247681NCI NIH HHS R21 CA185627NIGMS NIH HHS R01 GM084152NIGMS NIH HHS R01 GM132606
6 · The paper itself

Abstract

Multicellular biology is dependent on the control of cell-cell interactions. These concepts have begun to be exploited for engineering of cell-based therapies. Herein, we detail the use of a multivalent lipidated scaffold for the rapid and reversible manipulation of cell-cell interactions. Chemically self-assembled nanorings (CSANs) are formed

Identifiers

PMID34168743
PMCPMC8179657
OpenAlexW3097337992

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.