Evidence map›Paper›PMID 34168657›Full record

ArticleFrontiers in immunology2021

Bridging Computational Vaccinology and Vaccine Development Through Systematic Identification, Characterization, and Downselection of Conserved and Variable Circumsporozoite Protein CD4 T Cell Epitopes From Diverse

Amy R Noe, Frances E Terry, Brian C Schanen, Emily Sassano, Pooja Hindocha, Timothy W Phares, Leonard Moise, Jayne M Christen, Kenneth D Tucker, Vinayaka Kotraiah and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Amy R NoeLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Frances E TerryEpiVax Inc., Providence, RI, United States.
Brian C SchanenSanofi Pasteur, VaxDesign Campus, Orlando, FL, United States.
Emily SassanoSanofi Pasteur, VaxDesign Campus, Orlando, FL, United States.
Pooja HindochaEpiVax Inc., Providence, RI, United States.
Timothy W PharesLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Leonard MoiseEpiVax Inc., Providence, RI, United States.
Jayne M ChristenLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Kenneth D TuckerLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Vinayaka KotraiahLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Donald R DrakeSanofi Pasteur, VaxDesign Campus, Orlando, FL, United States.
William D MartinEpiVax Inc., Providence, RI, United States.
Anne S De GrootEpiVax Inc., Providence, RI, United States.
Gabriel M GutierrezLeidos Life Sciences, Leidos Inc., Frederick, MD, United States.
Leidos (United States) · USProvidence College · USSanofi (United States) · USEpiVax (United States) · USUniversity of Georgia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An effective malaria vaccine must prevent disease in a range of populations living in regions with vastly different transmission rates and protect against genetically-diverse

Indexed as

Drug DesignAntigens, ProtozoanCD4-Positive T-LymphocytesCells, CulturedComputer-Aided DesignCytokinesEpitopes, T-LymphocyteHigh-Throughput Screening AssaysHLA-DR AntigensHost-Parasite InteractionsHumansLymphocyte ActivationMalaria, FalciparumMalaria VaccinesPeptide FragmentsPlasmodium falciparumAntigens, Protozoancircumsporozoite protein, ProtozoanCytokinesEpitopes, T-LymphocyteHLA-DR AntigensMalaria VaccinesPeptide FragmentsProtozoan Proteinscross-strainCSPHLA-DRin silico epitope predictionmalariamultifunctional cytokine responseTH2R

Identifiers

PMID34168657
PMCPMC8217813
OpenAlexW3168140637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.