Evidence map›Paper›PMID 34168655›Full record

ArticleFrontiers in immunology2021

The Immune Atlas of Human Deciduas With Unexplained Recurrent Pregnancy Loss.

Pengfei Chen, Liying Zhou, Jiying Chen, Ying Lu, Chaoxia Cao, Shuangli Lv, Zhihong Wei, Liping Wang, Jiao Chen, Xinglin Hu and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. Pooled it
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  13. LAG-3 palmitoylation-inducing dysfunction of decidual CD4Molecular medicine (Cambridge, Mass.) · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Immune checkpoint for pregnancy.Seminars in immunopathology · 2025
    Review
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Pengfei ChenDepartment of Traumatic Orthopedics, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Liying ZhouDepartment of Gynaecology, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Jiying ChenDepartment of Gynaecology, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Ying LuShenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Chaoxia CaoDepartment of Gynaecology, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Shuangli LvDepartment of Gynaecology, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Zhihong WeiDepartment of Gynaecology, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Liping WangCentre of Reproductive Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Jiao ChenShenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Xinglin HuShenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Zijing WuShenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Xiaohua ZhouDepartment of Gynaecology, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Danna SuCentre of Reproductive Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Xuefeng DengDepartment of Traumatic Orthopedics, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Changchun ZengDepartment of Traumatic Orthopedics, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Huiyun WangState Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Zuhui PuDepartment of Radiology, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Ruiying DiaoCentre of Reproductive Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Lisha MouShenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Shenzhen Second People's Hospital · CNLonggang Central Hospital · CNShenzhen Bao'an District People's Hospital · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent pregnancy loss (RPL) is a common fertility problem that affects 1%-2% of couples all over the world. Despite exciting discoveries regarding the important roles of the decidual natural killer cell (dNK) and regulatory T cell in pregnancy, the immune heterogeneity in patients with unexplained recurrent pregnancy loss (URPL) remains elusive. Here, we profiled the transcriptomes of 13,953 CD45

Indexed as

Abortion, HabitualCD8-Positive T-LymphocytesDeciduaDendritic CellsFemaleHumansKiller Cells, NaturalMacrophagesPregnancyRNA-Seqhuman deciduaimmune heterogeneityscRNA decidual nature killer cellsingle-cell RNA sequencingthe immune atlasunexplained recurrent pregnancy loss

Identifiers

PMID34168655
PMCPMC8218877
OpenAlexW3172312035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.