Evidence map›Paper›PMID 34168393›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2020

Brain Metabolism Monitoring through CCO Measurements Using All-Fiber-Integrated Super-Continuum Source.

Mohammed N Islam, Kaiwen Guo, Tianqu Zhai, Allyssa K Memmini, Ramon Martinez, Cynthia N Meah, Ioulia Kovelman, Daniel Weissman, Xiaosu Hu, Jessica Kim and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Mohammed N IslamDepartment of Electrical and Computer Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Kaiwen GuoDepartment of Electrical and Computer Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Tianqu ZhaiDepartment of Electrical and Computer Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Allyssa K MemminiMichigan Concussion Center, University of Michigan, Ann Arbor, Michigan 48109, USA.
Ramon MartinezDepartment of Electrical and Computer Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Cynthia N MeahDepartment of Electrical and Computer Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Ioulia KovelmanDepartment of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Daniel WeissmanDepartment of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Xiaosu HuSchool of Dentistry, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Jessica KimDepartment of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Steven BroglioMichigan Concussion Center, University of Michigan, Ann Arbor, Michigan 48109, USA.
Daniel BeardDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Francoise VAN DEN BerghDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Hasan AlamDepartment of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.
Rachel RussoDepartment of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.
University of Michigan–Ann Arbor · USMichigan United · US

Funding

Impact of heritage language on bilingual children's path to English literacy (Diversity Supplement R01 HD092498)R01HD092498 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOVELMAN, IOULIA · 2018 to 2023
$2.1M
NICHD NIH HHS R01 HD092498
6 · The paper itself

Abstract

For monitoring of concussion, brain function, organ condition and other medical applications, what is needed is a non-invasive method of monitoring tissue metabolism. MRI-based functional imaging technology detects changes in blood oxygenation, a correlate of neural activity, and thus may offer a prediction of prognosis in cases of concussion and other cerebral traumas. Yet, potential relationships between perturbations to cerebral metabolism and patient outcomes cannot be effectively exploited clinically because we lack a practical, low-cost, non-invasive means to monitor cerebral oxygenation and metabolism in the emergency department, operating room, or medical facilities. We have developed a device to optically assay the redox state of Cytochrome-C-Oxidase (CCO), the mitochondrial enzyme responsible for the last step of the electron transport chain. Changes in CCO redox reflect changes in respiratory flux, and thus changes in the rate of oxidative adenosine triphosphate (ATP) synthesis. In other words, changes in CCO reflect brain cell's metabolic activity more directly than the traditional blood oxygenation measurement methods. To non-invasively measure changes in CCO as well as blood oxygenation, we have developed a Super-Continuum Infrared Spectroscopy of Cytochrome-C-Oxidase (SCISCCO) system that uses an all-fiber integrated, super-continuum light source to simultaneously measure both of the new (CCO) and the traditional (blood oxygenation) markers of neural metabolism. The SCISCCO system is validated by confirming the near-infrared spectrum of CCO

Identifiers

PMID34168393
PMCPMC8220891
OpenAlexW3008000413

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.