Evidence map›Paper›PMID 34168373›Full record

ArticleNature methods2021

Automatic detection of synaptic partners in a whole-brain Drosophila electron microscopy data set.

Julia Buhmann, Arlo Sheridan, Caroline Malin-Mayor, Philipp Schlegel, Stephan Gerhard, Tom Kazimiers, Renate Krause, Tri M Nguyen, Larissa Heinrich, Wei-Chung Allen Lee and 7 more

Open access · greenAbstract read
In one paragraph

Article in Nature methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.

  1. Pooled it
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  18. Connectomic mapping of pharyngeal and gut sensory circuits in adultbioRxiv : the preprint server for biology · 2025
    Article
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  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Julia BuhmannHHMI Janelia Research Campus, Ashburn, VA, USA.
Arlo SheridanHHMI Janelia Research Campus, Ashburn, VA, USA.ORCID http://orcid.org/0000-0003-2907-2254
Caroline Malin-MayorHHMI Janelia Research Campus, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-9627-6030
Philipp SchlegelMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-5633-1314
Stephan GerhardHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4454-6171
Tom KazimiersHHMI Janelia Research Campus, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-1605-9475
Renate KrauseHHMI Janelia Research Campus, Ashburn, VA, USA.ORCID http://orcid.org/0000-0001-9333-5245
Tri M NguyenHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9936-1794
Larissa HeinrichHHMI Janelia Research Campus, Ashburn, VA, USA.ORCID http://orcid.org/0000-0003-2852-6664
Wei-Chung Allen LeeF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4618-295X
Rachel WilsonHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8573-9266
Stephan SaalfeldHHMI Janelia Research Campus, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-4106-1761
Gregory S X E JefferisMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-0587-9355
Davi D BockUniversity of Vermont, Burlington, VA, USA.
Srinivas C TuragaHHMI Janelia Research Campus, Ashburn, VA, USA.ORCID http://orcid.org/0000-0003-3247-6487
Matthew CookInstitute of Neuroinformatics, University of Zurich and ETH Zurich, Zurich, Switzerland.
Jan FunkeHHMI Janelia Research Campus, Ashburn, VA, USA. funkej@janelia.hhmi.org.ORCID http://orcid.org/0000-0003-4388-7783
Janelia Research Campus · USHarvard University · USSIB Swiss Institute of Bioinformatics · CHMRC Laboratory of Molecular Biology · GBBoston Children's Hospital · USUniversity of Vermont · US

Funding

Automating whole brain connectomics: development, validation, and application of an open toolkitRF1MH120679 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOCK, DAVI · 2019 to 2019
$1.9M
Howard Hughes Medical InstituteMedical Research Council MC_U105188491NIMH NIH HHS RF1 MH120679Wellcome Trust 203261Wellcome Trust 203261/Z/16/Z
6 · The paper itself

Abstract

We develop an automatic method for synaptic partner identification in insect brains and use it to predict synaptic partners in a whole-brain electron microscopy dataset of the fruit fly. The predictions can be used to infer a connectivity graph with high accuracy, thus allowing fast identification of neural pathways. To facilitate circuit reconstruction using our results, we develop CIRCUITMAP, a user interface add-on for the circuit annotation tool CATMAID.

Indexed as

AnimalsBrainDatabases, FactualDrosophila melanogasterImage Processing, Computer-AssistedMicroscopy, ElectronNeural PathwaysSynapses

Identifiers

PMID34168373
PMCPMC7611460
OpenAlexW3174415204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.