ArticleThe ISME journal2021
Coral mucus rapidly induces chemokinesis and genome-wide transcriptional shifts toward early pathogenesis in a bacterial coral pathogen.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Crystal structure ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Coral larvae have unique transcriptomic responses to pathogenic and probiotic bacteria.Coral reefs (Online) · 2026Article
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- Quorum sensing regulates virulence factors in the coral pathogenApplied and environmental microbiology · 2025Article
- Microfluidic approaches in microbial ecology.Lab on a chip · 2024Review
- Coral thermal stress and bleaching enrich and restructure reef microbial communities via altered organic matter exudation.Communications biology · 2024Article
- Integrated metagenomic and metaproteomic analyses reveal bacterial micro-ecological mechanisms in coral bleaching.mSystems · 2023Article
- Coral Disease and Ingestion: Investigating the Role of Heterotrophy in the Transmission of PathogenicApplied and environmental microbiology · 2023Article
- Ecology of Endozoicomonadaceae in three coral genera across the Pacific Ocean.Nature communications · 2023Article
- Type VI Secretion Systems: Environmental and Intra-host Competition of Vibrio cholerae.Advances in experimental medicine and biology · 2023Article
- Role of the Vibriolysin VemA Secreted by the Emergent PathogenMicroorganisms · 2022Article
- Disease resistance in coral is mediated by distinct adaptive and plastic gene expression profiles.Science advances · 2022Article
- Coral holobiont cues prime Endozoicomonas for a symbiotic lifestyle.The ISME journal · 2022Article
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated seawater temperatures have contributed to the rise of coral disease mediated by bacterial pathogens, such as the globally distributed Vibrio coralliilyticus, which utilizes coral mucus as a chemical cue to locate stressed corals. However, the physiological events in the pathogens that follow their entry into the coral host environment remain unknown. Here, we present simultaneous measurements of the behavioral and transcriptional responses of V. coralliilyticus BAA-450 incubated in coral mucus. Video microscopy revealed a strong and rapid chemokinetic behavioral response by the pathogen, characterized by a two-fold increase in average swimming speed within 6 min of coral mucus exposure. RNA sequencing showed that this bacterial behavior was accompanied by an equally rapid differential expression of 53% of the genes in the V. coralliilyticus genome. Specifically, transcript abundance 10 min after mucus exposure showed upregulation of genes involved in quorum sensing, biofilm formation, and nutrient metabolism, and downregulation of flagella synthesis and chemotaxis genes. After 60 min, we observed upregulation of genes associated with virulence, including zinc metalloproteases responsible for causing coral tissue damage and algal symbiont photoinactivation, and secretion systems that may export toxins. Together, our results suggest that V. coralliilyticus employs a suite of behavioral and transcriptional responses to rapidly shift into a distinct infection mode within minutes of exposure to the coral microenvironment.
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