ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
The role of anterior insula-brainstem projections and alpha-1 noradrenergic receptors for compulsion-like and alcohol-only drinking.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Bad habits-good goals? Meta-analysis and translation of the habit construct to alcoholism.Translational psychiatry · 2024Pooled it
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Impact of adolescent social Isolation on increased risk for alcohol intake and aversion-resistant drinking in males and females.Research square · 2026Article
- Activation of Insula-Accumbal Projection Neurons Is Required for Relapse-Like Behaviour Following Opioid Self-Administration.Addiction biology · 2026Article
- α1 Adrenergic Receptors Mediate Panic-like Defensive Behavior in Alcohol-Drinking but Not Alcohol-Naïve Rats.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Noradrenergic Mechanisms and Circuitry of Hyperkatifeia in Alcohol Use Disorder.Biological psychiatry · 2025Review
- Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle.Current topics in behavioral neurosciences · 2025Review
- Punishment-resistant alcohol intake is mediated by the nucleus accumbens shell in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Insular cortex subregions have distinct roles in cued heroin seeking after extinction learning and prolonged withdrawal in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sex- and estrous-related response patterns for alcohol depend critically on the level of compulsion-like challenge.Progress in neuro-psychopharmacology & biological psychiatry · 2024Article
- Greater inhibition of female rat binge alcohol intake by adrenergic receptor blockers using a novel Two-Shot rat binge drinking model.Scientific reports · 2024Article
- Greater inhibition of female rat binge alcohol intake by adrenergic receptor blockers using a novel Two-Shot rat binge drinking model.Research square · 2024Article
- Sex differences in heart rate variability measures that predict alcohol drinking in rats.Addiction biology · 2024Article
- Engagement for alcohol escalates in the 5-choice serial reaction time task after intermittent access.Alcohol (Fayetteville, N.Y.) · 2024Article
- Neural Activity in the Anterior Insula at Drinking Onset and Licking Relates to Compulsion-Like Alcohol Consumption.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice.Neuropharmacology · 2024Article
- Non-Consummatory Behavior Signals Predict Aversion-Resistant Alcohol Drinking in Head-Fixed Mice.bioRxiv : the preprint server for biology · 2023Article
- Still a "hidden island"? The rodent insular cortex in drug seeking, reward, and risk.Neuroscience and biobehavioral reviews · 2023Review
- Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking.Addiction neuroscience · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compulsion-like alcohol drinking (CLAD), where consumption continues despite negative consequences, is a major obstacle to treating alcohol use disorder. The locus coeruleus area in the brainstem and norepinephrine receptor (NER) signaling in forebrain cortical regions have been implicated in adaptive responding under stress, which is conceptually similar to compulsion-like responding (adaptive responding despite the presence of stress or conflict). Thus, we examined whether anterior insula (aINS)-to-brainstem connections and alpha-1 NERs regulated compulsion-like intake and alcohol-only drinking (AOD). Halorhodopsin inhibition of aINS-brainstem significantly reduced CLAD, with no effect on alcohol-only or saccharin intake, suggesting a specific aINS-brainstem role in aversion-resistant drinking. In contrast, prazosin inhibition of alpha-1 NERs systemically reduced both CLAD and AOD. Similar to systemic inhibition, intra-aINS alpha-1-NER antagonism reduced both CLAD and AOD. Global aINS inhibition with GABAR agonists also strongly reduced both CLAD and AOD, without impacting saccharin intake or locomotion, while aINS inhibition of calcium-permeable AMPARs (with NASPM) reduced CLAD without impacting AOD. Finally, prazosin inhibition of CLAD and AOD was not correlated with each other, systemically or within aINS, suggesting the possibility that different aINS pathways regulate CLAD versus AOD, which will require further study to definitively address. Together, our results provide important new information showing that some aINS pathways (aINS-brainstem and NASPM-sensitive) specifically regulate compulsion-like alcohol consumption, while aINS more generally may contain parallel pathways promoting CLAD versus AOD. These findings also support the importance of the adaptive stress response system for multiple forms of alcohol drinking.
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