Evidence map›Paper›PMID 34168277›Full record

ArticleInternational journal of obesity (2005)2021

Performance of non-invasive fibrosis scores in non-alcoholic fatty liver disease with and without morbid obesity.

Andreas Drolz, Stefan Wolter, Malte H Wehmeyer, Felix Piecha, Thomas Horvatits, Julian Schulze Zur Wiesch, Ansgar W Lohse, Oliver Mann, Johannes Kluwe

Open access · hybridAbstract read
In one paragraph

Article in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Diabetes and obesity reduce FIB-4 accuracy in MASLD referral pathways.JHEP reports : innovation in hepatology · 2026
    Article
  5. Article
  6. Noninvasive Markers of Hepatic Steatosis and Fibrosis Following Integrase Strand-Transfer Inhibitor Initiation in Women With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
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  10. Observational
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Andreas Drolz *I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. a.drolz@uke.de.ORCID http://orcid.org/0000-0002-2717-8517
Stefan Wolter *Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Malte H WehmeyerI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Felix PiechaI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thomas HorvatitsI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Julian Schulze Zur WieschI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ansgar W LohseI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Oliver MannDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Johannes KluweI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Universität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-invasive scores, such as the non-alcoholic fatty liver disease (NAFLD) Fibrosis Score (NFS), are increasingly used for liver fibrosis assessment in patients with NAFLD. The aim of this study was to assess the applicability and reliability of non-invasive fibrosis scores in NAFLD patients with and without morbid obesity.

methodsThree hundred sixty-eight patients with biopsy-proven NAFLD identified between January 2012 and December 2015 were studied; 225 with morbid obesity (biopsy obtained during bariatric surgery) and 143 patients without (termed as "conventional").

resultsMedian age was 47 years, 57% were female. Median body mass index (BMI) was 42.9 kg/m

conclusionsOur data suggest that FIB-4 score is an accurate predictor of advanced fibrosis in NAFLD throughout all BMI stages. Without adjustment, NFS tends to overestimate fibrosis in morbidly obese NAFLD patients. This problem may be solved by implementation of an upper BMI limit (for NFS) or adjustment of diagnostic thresholds.

Indexed as

Severity of Illness IndexAdultArea Under CurveBody Mass IndexFemaleFibrosisHumansMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseObesity, MorbidReproducibility of ResultsROC Curve

Identifiers

PMID34168277
PMCPMC8455320
OpenAlexW3173267988

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.