ReviewPediatric research2022
Visuopathy of prematurity: is retinopathy just the tip of the iceberg?
Review in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07427719 (Children Treated for Retinopathy of Prematurity - Study of Visual Function and Retinal Structure), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Children Treated for Retinopathy of Prematurity - Study of Visual Function and Retinal Structure
Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Retinopathy of Prematurity Is Associated With Reduced Thalamic Volume and Impaired Neurodevelopment. A Cohort Study.Journal of paediatrics and child health · 2026Article
- Retinopathy of prematurity: Moving beyond oxygen.Early human development · 2026Review
- Ophthalmological outcomes, visual perception, fine motor precision, and visual-motor integration in children born very preterm.Developmental medicine and child neurology · 2026Article
- Construction of a prediction model for retinopathy of prematurity based on placenta-derived genes and clinical variables.Translational pediatrics · 2026Article
- Fixation and saccadic performance throughout childhood in children born preterm: A multicenter eye-tracking study.Pediatric research · 2026Article
- Article
- Targeting adenosine APurinergic signalling · 2025Review
- Neurofilament light chain associates with IVH and ROP in extremely preterm infants.Pediatric research · 2025Article
- Predictors of language and reading outcomes in 12-year-old children born very preterm.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Retrospective observational cohort study of premature neonates screened for ROP with 7 years of follow-up assessing the visual outcomes and adequacy of preschool visual screening.BMJ open ophthalmology · 2024Observational
- Relations between Neurocognitive Function and Visual Acuity: A Cross-Sessional Study in a Cohort of Premature Children.Children (Basel, Switzerland) · 2024Article
- Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants.JAMA network open · 2024Article
- Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight.Scientific reports · 2024Article
- Neonatal sepsis as a cause of retinopathy of prematurity: An etiological explanation.Progress in retinal and eye research · 2024Review
- A novel marker for predicting type 1 retinopathy of prematurity: C-reactive protein/albumin ratio.International ophthalmology · 2023Article
- Retinal structure and visual pathway function at school age in children born extremely preterm: a population-based study.BMC ophthalmology · 2023Article
- Extreme prematurity: Risk and resiliency.Current problems in pediatric and adolescent health care · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research on retinopathy of prematurity (ROP) focuses mainly on the abnormal vascularization patterns that are directly visible for ophthalmologists. However, recent findings indicate that children born prematurely also exhibit changes in the retinal cellular architecture and along the dorsal visual stream, such as structural changes between and within cortical areas. Moreover, perinatal sustained systemic inflammation (SSI) is associated with an increased risk for ROP and the visual deficits that follow. In this paper, we propose that ROP might just be the tip of an iceberg we call visuopathy of prematurity (VOP). The VOP paradigm comprises abnormal vascularization of the retina, alterations in retinal cellular architecture, choroidal degeneration, and abnormalities in the visual pathway, including cortical areas. Furthermore, VOP itself might influence the developmental trajectories of cerebral structures and functions deemed responsible for visual processing, thereby explaining visual deficits among children born preterm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.