Evidence map›Paper›PMID 34168256›Full record

ArticleScientific reports2021

Impact of acute ethanol intake on cardiac autonomic regulation.

Stefan Brunner, Raphaela Winter, Christina Werzer, Lukas von Stülpnagel, Ina Clasen, Annika Hameder, Andreas Stöver, Matthias Graw, Axel Bauer, Moritz F Sinner

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Acute effects of binge drinking following aerobic exercise on autonomic and hemodynamic recovery in young men: a randomized crossover trial.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  2. Article
  3. Modifiable Risk Factors in Atrial Fibrillation: Clinical Implications and Pathophysiological Insights.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Alcohol and Cardiac Arrythmias: A Review of the Current Data.Reviews in cardiovascular medicine · 2023
    Review
  12. Holiday heart syndrome: do not drink during this holiday! and other updates on recent autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Stefan BrunnerDepartment of Medicine I, University Hospital, Ludwig Maximilians University (LMU) Munich, Ziemssenstrasse 1, 80336, Munich, Germany. stefan.brunner@med.uni-muenchen.de.
Raphaela WinterDepartment of Medicine I, University Hospital, Ludwig Maximilians University (LMU) Munich, Ziemssenstrasse 1, 80336, Munich, Germany.
Christina WerzerDepartment of Medicine I, University Hospital, Ludwig Maximilians University (LMU) Munich, Ziemssenstrasse 1, 80336, Munich, Germany.
Lukas von StülpnagelDepartment of Medicine I, University Hospital, Ludwig Maximilians University (LMU) Munich, Ziemssenstrasse 1, 80336, Munich, Germany.
Ina ClasenInstitute of Legal Medicine, LMU Munich, Munich, Germany.
Annika HamederInstitute of Legal Medicine, LMU Munich, Munich, Germany.
Andreas StöverInstitute of Legal Medicine, LMU Munich, Munich, Germany.
Matthias GrawInstitute of Legal Medicine, LMU Munich, Munich, Germany.
Axel BauerGerman Center for Cardiovascular Research (DZHK), Partner Site: Munich Heart Alliance, Munich, Germany.
Moritz F SinnerDepartment of Medicine I, University Hospital, Ludwig Maximilians University (LMU) Munich, Ziemssenstrasse 1, 80336, Munich, Germany. moritz.sinner@med.uni-muenchen.de.
Ludwig-Maximilians-Universität München · DEGerman Centre for Cardiovascular Research · DEInnsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute alcohol consumption may facilitate cardiac arrhythmias underlying the 'Holiday Heart Syndrome'. Autonomic imbalance is promoting atrial arrhythmias. We analyzed the effects of alcohol on measures of the cardiac autonomic nervous system and their relation to arrhythmias. In 15 healthy individuals, alcohol was administered parenterally until a breath alcohol concentration of 0.50 mg/l. High-resolution digital 30-min ECGs were recorded at baseline, at the time of maximum alcohol concentration, and after alcohol concentration returned to near baseline. Using customized software, we assessed periodic repolarization dynamics (PRD), deceleration capacity (DC), standard measures of heart rate variability (SDNN; RMSSD; LF; HF), and standard ECG parameters (mean heart rate; PQ; QRS; QTc interval). At the maximum alcohol concentration, PRD levels were significantly increased compared to baseline [1.92 (IQR 1.14-3.33) deg

Indexed as

AdultAlcoholic IntoxicationArrhythmias, CardiacBreath TestsElectrocardiographyEthanolFemaleHeart RateHumansMaleMiddle AgedYoung AdultEthanol

Identifiers

PMID34168256
PMCPMC8225621
OpenAlexW3174580331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.