ArticleScientific reports2021
A computational model of the epidermis with the deformable dermis and its application to skin diseases.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Artificial intelligence-based quantification of epidermal proliferation and apoptosis in human skin.JID innovations : skin science from molecules to population health · 2026Article
- Spectroscopic Analysis of the Extracellular Matrix Hierarchical Structure in Naked Mole-Rat Skin.Gels (Basel, Switzerland) · 2026Article
- Skin in the game: a review of computational models of the skin.BioData mining · 2025Review
- Numerical investigation of new rete ridge formation in a multi-layer model of skin subjected to tissue expansion.Journal of biomechanics · 2024Article
- Antiproliferative and Anti-Inflammatory Effects of the Polyphenols Phloretin and Balsacone C in a Coculture of T Cells and Psoriatic Keratinocytes.International journal of molecular sciences · 2024Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Zonula occludens-1 distribution and barrier functions are affected by epithelial proliferation and turnover rates.Cell proliferation · 2023Article
- Individualised computational modelling of immune mediated disease onset, flare and clearance in psoriasis.PLoS computational biology · 2022Article
- Multiscale modelling of desquamation in the interfollicular epidermis.PLoS computational biology · 2022Article
- Short Practical Regimen of Acupuncture for Melasma: A Prospective Cohort Study in a Tertiary Hospital in Thailand.Frontiers in public health · 2021Observational
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Authors and funding
9 authors at 5 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The skin barrier is provided by the organized multi-layer structure of epidermal cells, which is dynamically maintained by a continuous supply of cells from the basal layer. The epidermal homeostasis can be disrupted by various skin diseases, which often cause morphological changes not only in the epidermis but in the dermis. We present a three-dimensional agent-based computational model of the epidermis that takes into account the deformability of the dermis. Our model can produce a stable epidermal structure with well-organized layers. We show that its stability depends on the cell supply rate from the basal layer. Modeling the morphological change of the dermis also enables us to investigate how the stiffness of the dermis affects the structure and barrier functions of the epidermis. Besides, we show that our model can simulate the formation of a corn (clavus) by assuming hyperproliferation and rapid differentiation. We also provide experimental data for human corn, which supports the model assumptions and the simulation result.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.